Catalytic Lactonization of Unactivated Aryl C-H Bonds with CO2: Experimental and Computational Investigation.
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DOI: 10.1021/acs.orglett.8b01363
Abstract: The first catalytic lactonization of unactivated aryl C-H bonds with CO2 to afford important phthalides is reported. Notably, this method features high selectivity, excellent functional group tolerance, smooth scalability, and facile product diversification. DFT calculations… read more here.
Keywords: bonds co2; aryl bonds; lactonization unactivated; catalytic lactonization ... See more keywords
Carboxylic Acid Directed γ-Lactonization of Unactivated Primary C–H Bonds Catalyzed by Mn Complexes: Application to Stereoselective Natural Product Diversification
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08620
Abstract: Reactions that enable selective functionalization of strong aliphatic C–H bonds open new synthetic paths to rapidly increase molecular complexity and expand chemical space. Particularly valuable are reactions where site-selectivity can be directed toward a specific… read more here.
Keywords: carboxylic acid; unactivated primary; lactonization; primary bonds ... See more keywords