Modification of α-lactose monohydrate as a direct compression excipient using roller compaction
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1508224
Abstract: Abstract Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted… read more here.
Keywords: roller compaction; excipient; compaction; lactose monohydrate ... See more keywords
Mechanical Transformation of Compounds Leading to Physical, Chemical, and Biological Changes in Pharmaceutical Substances
Sign Up to like & getrecommendations! Published in 2018 at "The Scientific World Journal"
DOI: 10.1155/2018/8905471
Abstract: This study demonstrates the link between the modification of the solid-phase pharmaceutical substances mechanical structure and their activity in waters with different molar ratio «deuterium-protium». Mechanochemical transformation of the powders of lactose monohydrate and sodium… read more here.
Keywords: pharmaceutical substances; mechanical transformation; chemical biological; substances mechanical ... See more keywords
A study of a novel coprocessed dry binder composed of α-lactose monohydrate, microcrystalline cellulose and corn starch
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Development and Technology"
DOI: 10.3109/10837450.2015.1131717
Abstract: Abstract This paper deals with a study of the novel coprocessed dry binder Combilac®, which contains 70% of α-lactose monohydrate, 20% of microcrystalline cellulose and 10% of native corn starch. These tests include flow properties,… read more here.
Keywords: microcrystalline cellulose; combilac; corn starch; monohydrate microcrystalline ... See more keywords
Crystallization Thermodynamics of α-Lactose Monohydrate in Different Solvents
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DOI: 10.3390/pharmaceutics14091774
Abstract: It is common to find that some of the lactose in dairy powders and pharmaceutical tablets is present in the unstable amorphous state. Therefore, their crystallization thermodynamics in different solvents are particularly important. In this… read more here.
Keywords: different solvents; solubility; thermodynamics; crystallization thermodynamics ... See more keywords