Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00756
Abstract: Tendinopathy is a disease with surging prevalence. Lacking understanding of molecular mechanisms impedes the development of therapeutic approaches and agents. Lysine lactylation (Kla) is a newly discovered post-translational modification related to glycolysis. It has long… read more here.
Keywords: metabolism; lactylation; matrix cholesterol; tendon ... See more keywords
Glypican-3 knockdown inhibits the cell growth, stemness, and glycolysis development of hepatocellular carcinoma cells under hypoxic microenvironment through lactylation.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2023.2206982
Abstract: CONTEXT Hepatocellular carcinoma (HCC) is a common malignant tumour in China. Glypican-3 (GPC3) is reported to be closely related to the occurrence and development of various tumours. OBJECTIVE This study aimed to explore the role… read more here.
Keywords: hepatocellular carcinoma; development; glypican knockdown; knockdown inhibits ... See more keywords
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjac073
Abstract: ABSTRACT Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle… read more here.
Keywords: promotes hypoxic; pulmonary hypertension; glycolytic shift; lactylation ... See more keywords
Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000279
Abstract: BACKGROUND AND AIMS NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier (MPC1) and inflammation, fibrosis, and insulin sensitivity in obese or NASH mouse… read more here.
Keywords: acid synthase; pyruvate carrier; lactylation; mitochondrial pyruvate ... See more keywords
Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction
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DOI: 10.1161/circresaha.122.320488
Abstract: Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation. However, the role of histone lactylation in… read more here.
Keywords: histone lactylation; post; lactylation; reparative gene ... See more keywords
BRAFV600E restructures cellular lactylation to promote anaplastic thyroid cancer proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Endocrine-related cancer"
DOI: 10.1530/erc-22-0344
Abstract: Anaplastic thyroid cancer (ATC) is a rare but fatal cancer with BRAF mutation ranging from 30%-50%. Histone lysine lactylation represents a novel epigenetic mark that translates cellular metabolic signals into transcriptional regulation. It is not… read more here.
Keywords: cellular lactylation; proliferation; brafv600e; lactylation ... See more keywords
ULK1-mediated metabolic reprogramming regulates Vps34 lipid kinase activity by its lactylation.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.2139/ssrn.4047255
Abstract: Autophagy and glycolysis are highly conserved biological processes involved in both physiological and pathological cellular programs, but the interplay between these processes is poorly understood. Here, we show that the glycolytic enzyme lactate dehydrogenase A… read more here.
Keywords: kinase activity; lipid kinase; lactylation; kinase ... See more keywords
The role and mechanism of histone lactylation in health and diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.949252
Abstract: Whether under anaerobic or aerobic conditions, glycolysis results in production of lactate. Increasing evidence suggests that lactate serves as a multifunctional signaling molecule that develops non-metabolic activities in addition to serving as a key metabolite… read more here.
Keywords: lactylation; histone lactylation; role mechanism; mechanism histone ... See more keywords
Post-translational changes in Phialophora verrucosa via lysine lactylation during prolonged presence in a patient with a CARD9-related immune disorder
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.966457
Abstract: CARD9-related inherited immune disorders are a major risk factor for chronic disseminated fungal infection. In addition to pathogens of Candida and dermatophytes, the environmental opportunists of the black yeast-like fungi are relatively frequent in this… read more here.
Keywords: post translational; card9 related; lactylation; lysine lactylation ... See more keywords
Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1149989
Abstract: Background The epigenetic regulatory chemical lactate is a product of glycolysis. It can regulate gene expression through histone lactylation, thereby promoting tumor proliferation, metastasis, and immunosuppression. Methods In this study, a lactylation-related model for gastric… read more here.
Keywords: response; lactylation related; related model; lactylation ... See more keywords
Lactylation may be a Novel Posttranslational Modification in Inflammation in Neonatal Hypoxic-Ischemic Encephalopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.926802
Abstract: Perinatal hypoxia-ischemia remains the most common cause of acute neonatal brain injury and is associated with a high death rate and long-term neurological abnormalities such as memory and cognitive deficits and dyskinesia. Hypoxia-ischemia triggers an… read more here.
Keywords: inflammation; hypoxic ischemic; lactylation; brain ... See more keywords