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   Articles with "lactylation" as a keyword



Histone H3K9 Lactylation Confers Temozolomide Resistance in Glioblastoma via LUC7L2‐Mediated MLH1 Intron Retention

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202309290

Abstract: Temozolomide (TMZ) resistance remains the major obstacle in the treatment of glioblastoma (GBM). Lactylation is a novel post‐translational modification that is involved in various tumors. However, whether lactylation plays a role in GBM TMZ resistance… read more here.

Keywords: resistance; histone h3k9; lactylation; gbm ... See more keywords

Aloe Emodin Alleviates Radiation‐Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202406026

Abstract: Aloe emodin is an anthraquinone of traditional Chinese medicine monomer, which plays a protective action in cardiovascular diseases. However, the regulatory mechanisms of aloe emodin in the protection of radiation‐induced heart damage (RIHD) are unclear.… read more here.

Keywords: induced heart; radiation induced; lactylation; aloe emodin ... See more keywords

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202500963

Abstract: Increasing evidence has clarified that atrial fibrillation (AF) is associated with enhanced glycolysis, leading to lactate accumulation. However, whether glycolysis promotes AF remains unknown, as does whether histone lactylation plays a role in its pathogenesis.… read more here.

Keywords: pfkm; lactylation; glycolysis; histone lactylation ... See more keywords

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202504028

Abstract: Sleep deprivation critically disrupts physiological homeostasis, impairing development, metabolic balance, and immune regulation, with excessive neutrophil activation being a hallmark consequence. However, the molecular mechanisms underlying sleep deprivation‐induced neutrophilic inflammation remain elusive. Here, it is… read more here.

Keywords: sleep deprivation; deprivation; ror; lactylation ... See more keywords

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202506529

Abstract: Esophageal squamous cell carcinoma (ESCC) is a common digestive tract malignant cancer with high incidence and mortality rate. Many studies have shown that long noncoding RNAs (lncRNAs are involved in the progression of various types… read more here.

Keywords: esophageal squamous; progression; lactylation; squamous cell ... See more keywords

Lactylation-Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22-Mediated Dephosphorylation of NLRP3.

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recommendations! Published in 2025 at "Advanced science"

DOI: 10.1002/advs.202510192

Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) is among the most prevalent chronic liver diseases worldwide. The expression of YTH domain-containing protein 1 (YTHDC1) is significantly reduced in patients and mouse models with MASLD. Hepatocyte-specific knockout… read more here.

Keywords: mediated dephosphorylation; alleviates masld; lactylation; ptpn22 mediated ... See more keywords

Histone lactylation facilitates hepatocellular carcinoma progression by upregulating endothelial cell‐specific molecule 1 expression

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recommendations! Published in 2024 at "Molecular Carcinogenesis"

DOI: 10.1002/mc.23794

Abstract: Hepatocellular carcinoma (HCC) is a common malignant tumor. Histone lactylation, a novel epigenetic modification, plays a crucial role in various cancers. However, the functional role and underlying mechanism of histone lactylation in HCC progression have… read more here.

Keywords: role; hcc; lactylation; cell ... See more keywords

Jatrorrhizine Alleviates Calcific Aortic Valve Disease via Interfering With Glycolysis Targeting ALDOA K42 Lactylation

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recommendations! Published in 2025 at "Phytotherapy Research"

DOI: 10.1002/ptr.8504

Abstract: Calcific aortic valve disease (CAVD) is a common cardiovascular disorder. It is characterized by the thickening, fibrosis, and mineralization of aortic valve leaflets. These pathological changes can progress to heart failure if not managed effectively.… read more here.

Keywords: jat; valve; lactylation; aortic valve ... See more keywords

Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.

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recommendations! Published in 2023 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.2c00756

Abstract: Tendinopathy is a disease with surging prevalence. Lacking understanding of molecular mechanisms impedes the development of therapeutic approaches and agents. Lysine lactylation (Kla) is a newly discovered post-translational modification related to glycolysis. It has long… read more here.

Keywords: metabolism; lactylation; matrix cholesterol; tendon ... See more keywords

Global Profiling of Lactylation Proteomics and Specific Lactylated Site Validation in Rheumatoid Arthritis Patients.

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recommendations! Published in 2025 at "Journal of proteome research"

DOI: 10.1021/acs.jproteome.4c00680

Abstract: Protein lactylation is a novel post-translational modification that has rarely been investigated in rheumatoid arthritis (RA). This study aimed to explore lactylation proteomics in RA patients and validate sorted candidate lactylation sites. Synovial tissues from… read more here.

Keywords: lactylated modification; rheumatoid arthritis; lactylation; lactylation proteomics ... See more keywords

KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression

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recommendations! Published in 2025 at "Cell Death and Differentiation"

DOI: 10.1038/s41418-025-01533-4

Abstract: Histone lactylation is a novel epigenetic modification derived from lactate, but its role and mechanism in KRAS mutant colorectal cancer (CRC) progression remains to be fully elucidated. In this study, we first showed that mutant… read more here.

Keywords: lactylation h3k9la; progression; lactylation; h3k9la ... See more keywords