Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22270
Abstract: KCNJ4 (potassium voltage‐gated channel subfamily J member 4) belongs to the inward rectifier potassium channel family, which is inhibited by novel anticancer agents. However, the biologic significance of KCNJ4 in lung adenocarcinoma (LADC) is largely… read more here.
Keywords: kcnj4; lung adenocarcinoma; ladc; cancer ... See more keywords
Blocking MMP-12-modulated epithelial-mesenchymal transition by repurposing penfluridol restrains lung adenocarcinoma metastasis via uPA/uPAR/TGF-β/Akt pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular oncology"
DOI: 10.1007/s13402-021-00620-1
Abstract: PURPOSE Metastasis of lung adenocarcinoma (LADC) is a crucial factor determining patient survival. Repurposing of the antipsychotic agent penfluridol has been found to be effective in the inhibition of growth of various cancers. As yet,… read more here.
Keywords: lung adenocarcinoma; ladc cells; mmp; metastasis ... See more keywords
The effects of bisphosphonate and radiation therapy in bone-metastatic lung adenocarcinoma: the impact of KRAS mutation.
Sign Up to like & getrecommendations! Published in 2021 at "Translational lung cancer research"
DOI: 10.21037/tlcr-20-754
Abstract: Background KRAS mutation is the most common genetic alteration in lung adenocarcinoma (LADC) in Western countries and is associated with worse outcome in bone-metastatic cases. Yet, to date, no effective treatment guidelines were developed for… read more here.
Keywords: kras mutation; bone metastatic; ladc; mutation ... See more keywords
Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.652193
Abstract: Background Micropapillary adenocarcinoma is one of the most aggressive histologic subtypes of lung adenocarcinoma (LADC), and even a minor proportion of micropapillary component (MPC) within the LADC could contribute to poor prognosis. Comprehensive analysis of… read more here.
Keywords: lung adenocarcinoma; mpc; micropapillary component; immunological features ... See more keywords