Basal Autophagy Is Altered in Lagotto Romagnolo Dogs with an ATG4D Mutation
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary Pathology"
DOI: 10.1177/0300985817712793
Abstract: A missense variant in the autophagy-related ATG4D-gene has been associated with a progressive degenerative neurological disease in Lagotto Romagnolo (LR) dogs. In addition to neural lesions, affected dogs show an extraneural histopathological phenotype characterized by… read more here.
Keywords: microscopy; basal autophagy; romagnolo dogs; lagotto romagnolo ... See more keywords
PKD1 Nonsense Variant in a Lagotto Romagnolo Family with Polycystic Kidney Disease
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14061210
Abstract: A female Lagotto Romagnolo dog with polycystic kidney disease (PKD) and her progeny, including PKD-affected offspring, were studied. All affected dogs appeared clinically inconspicuous, while sonography revealed the presence of renal cysts. The PKD-affected index… read more here.
Keywords: nonsense variant; lagotto romagnolo; pkd1; polycystic kidney ... See more keywords