A novel mechanism of cannabidiol in suppressing ovarian cancer through LAIR‐1 mediated mitochondrial dysfunction and apoptosis
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Toxicology"
DOI: 10.1002/tox.23752
Abstract: Cannabidiol (CBD) is a nonpsychoactive cannabinoid compound. It has been shown that CBD can inhibit the proliferation of ovarian cancer cells, but the underlying specific mechanism is unclear. We previously presented the first evidence for… read more here.
Keywords: lair; cancer cells; cbd; ovarian cancer ... See more keywords
Clinicopathologic significance of LAIR-1 expression in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2019 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2018.04.005
Abstract: AIM Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is an immune inhibitory receptor which is expressed within most types of hematopoietic cells and negatively regulates immune responses. Recently, we found LAIR-1 expression to be present within tumors of… read more here.
Keywords: hcc; lair; tissue; expression ... See more keywords
Silencing LAIR‐1 in human THP‐1 macrophage increases foam cell formation by modulating PPAR&ggr; and M2 polarization
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.08.028
Abstract: Graphical abstract Figure. No caption available. HighlightsLAIR‐1 was down‐regulated in macrophage with the stimulation of ox‐LDL.Silencing expression of LAIR‐1 in human macrophages increased cholesterol uptake.LAIR‐1 activated phosphorylation of SHP‐1 and CREB to induce PPAR&ggr;, thus… read more here.
Keywords: cell formation; lair; foam cell; ppar ggr ... See more keywords
04 Construction and analysis of lair-1 over-expressed nk-92 cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Investigative Medicine"
DOI: 10.1136/jim-2017-mebabstracts.4
Abstract: Background LAIR-1 can be triggered by collagen and its intracellular ITIMs are crucial for the inhibitory signal to NK cells. In order to investigate the regulation mechanisms of LAIR-1/collagen on NK cells, we aimed to… read more here.
Keywords: lair; analysis; western blot; expressed cells ... See more keywords
694 NC410 is a novel immunomedicine for the treatment of solid tumors
Sign Up to like & getrecommendations! Published in 2020 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.1136/jitc-2020-sitc2020.0694
Abstract: Background Abnormalities in the extracellular matrix of tumor microenvironments support tumor progression, lead to immune dysfunction, and provide a target for cancer therapeutics. Collagens are a primary component of the extracellular matrix. Abnormal levels of… read more here.
Keywords: collagen; lair; nc410 novel; function ... See more keywords
Increased concentration of soluble leukocyte-associated immunoglobulin-like receptor (LAIR) in sera from patients with blistering diseases: possible pathophysiological implications?
Sign Up to like & getrecommendations! Published in 2022 at "Minerva medica"
DOI: 10.23736/s0026-4806.22.07652-2
Abstract: BACKGROUND Autoimmune Blistering Diseases (AIBD), are a heterogeneous group. Despite their pathogenesis is not completely understood, autoantibodies against directed adhesion molecules of the skin and adjacent mucous membranes could play a key role. The leukocyte-associated-Ig-like-receptor… read more here.
Keywords: lair; blistering diseases; receptor lair; like receptor ... See more keywords
Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00747
Abstract: The interaction between collagen/collagen-like peptides and the commonly expressed immune cell receptor LAIR-1 (leukocyte-associated immunoglobulin-like receptor-1) regulates and directs immune responses throughout the body. Understanding and designing these interactions within the context of biomaterials could… read more here.
Keywords: collagen; surface bound; macrophage uptake; lair ... See more keywords