Long‐Lasting Protection and Dose Optimization of MPXV Polyvalent Mpox mRNA Vaccines Against Lethal Vaccinia Virus Challenge in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.70143
Abstract: The outbreak of clade II monkeypox virus (MPXV) and the additional outbreak in Central Africa of clade I virus from 2023 have attracted worldwide attention. The development of a scalable and effective vaccine against the… read more here.
Keywords: protection; virus; challenge; mrna vaccines ... See more keywords
Low appendicular muscle mass is associated with mortality in peritoneal dialysis patients: a single-center cohort study
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Clinical Nutrition"
DOI: 10.1038/ejcn.2017.104
Abstract: Background/Objectives:There are few studies of the association between low appendicular muscle mass (LAM) and clinical outcomes in peritoneal dialysis (PD) patients. We aimed to determine the clinical association between LAM and clinical outcomes in PD… read more here.
Keywords: lam; appendicular muscle; mass; muscle mass ... See more keywords
mTOR dysregulation induces IL-6 and paracrine AT2 cell senescence impeding lung repair in lymphangioleiomyomatosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-64036-3
Abstract: Lymphangioleiomyomatosis (LAM) is a rare disease of women in which TSC2 deficient ‘LAM cells’ with dysregulated mTOR signalling and recruited fibroblasts form nodules causing lung cysts and respiratory failure. We examine if mTOR dysregulation can… read more here.
Keywords: senescence; lymphangioleiomyomatosis; lung; mtor ... See more keywords
A new 1 : 1 cocrystal of lamotrigine and 1,2,3,6-hydrophthalimide: discovery, characterization, and construction of ternary phase diagrams
Sign Up to like & getrecommendations! Published in 2020 at "CrystEngComm"
DOI: 10.1039/d0ce00178c
Abstract: A 1 : 1 cocrystal of lamotrigine (LAM) and 1,2,3,6-hydrophthalimide (HPHT) was successfully synthesized for the first time and was characterized by XRD (powder and single-crystal X-ray diffraction), FT-IR, DSC and TG. Molecular Hirshfeld surfaces and the… read more here.
Keywords: cocrystal lamotrigine; lam; ternary phase; solubility ... See more keywords
Prospective nanoparticle treatments for lymphangioleiomyomatosis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2029401
Abstract: ABSTRACT Introduction Lymphangioleiomyomatosis (LAM) is a rare lung disease that is characterized by smooth muscle-like cell growth in the lungs. The current available oral treatment rapamycin slows down the disease progression but does not result… read more here.
Keywords: prospective nanoparticle; treatments lymphangioleiomyomatosis; lam; nanoparticle treatments ... See more keywords
A Flavonoid Concentrate from Moringa Oleifera Lam. Leaves Extends Exhaustive Swimming Time by Improving Energy Metabolism and Antioxidant Capacity in Mice
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Food"
DOI: 10.1089/jmf.2023.k.0114
Abstract: Moringa oleifera Lam. leaves contain various nutrients and bioactive compounds. The present study aimed to assess the anti-fatigue capacity of a flavonoids concentrate purified from M. oleifera Lam. leaves. The total flavonoids in the purified… read more here.
Keywords: swimming; lam leaves; metabolism; oleifera lam ... See more keywords
Clinic-Based Urinary Lipoarabinomannan as a Biomarker of Clinical Disease Severity and Mortality Among Antiretroviral Therapy-Naive Human Immunodeficiency Virus-Infected Adults in South Africa
Sign Up to like & getrecommendations! Published in 2017 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofx167
Abstract: Abstract Background Urinary lipoarabinomannan (LAM) has limited sensitivity for diagnosing active human immunodeficiency virus (HIV)-associated tuberculosis (TB) disease, but LAM screening at HIV diagnosis might identify adults with more severe clinical disease or greater risk… read more here.
Keywords: clinical disease; lam; disease; mortality ... See more keywords
PERFORMANCE OF XPERT MTB/RIF AND DETERMINE LAM IN HIV-INFECTED ADULTS IN PERI-URBAN SITES IN ZAMBIA (CDC OP-X STUDY)
Sign Up to like & getrecommendations! Published in 2017 at "BMJ Global Health"
DOI: 10.1136/bmjgh-2016-000260.14
Abstract: Background Tuberculosis (TB) mortality in HIV-infected patients remains high in sub-Saharan Africa. Inadequate diagnostic tools delay time to TB treatment. Methods A two-phase TB diagnostic study was conducted among HIV-infected adult patients from 2014–2016. Patients… read more here.
Keywords: lam; treatment; hiv; culture ... See more keywords
Phenotypic characterization of primary non-nodular and nodular lymphangeioleiomyomatosis (LAM) cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5729564
Abstract: Background: Lymphangioleiomyomatosis (LAM) is a rare lung disease that predominantly develops in women between the ages of 20–40 years. The main characteristics of LAM are metastatic spread and infiltration of tissues by proliferative, abnormal smooth… read more here.
Keywords: non nodular; nodular lam; lam cells; physiology ... See more keywords
HOX/PBX Inhibition Attenuates Tsc2-Null Cell Viability and Lung Metastasis in Lymphangioleiomyomatosis
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732717
Abstract: Lymphangioleiomyomatosis (LAM) is a rare lung disease that exclusively affects premenopausal women. LAM is caused by infiltration of metastasizing atypical smooth muscle-like cells into the lungs leading to progressive respiratory failure. Though the origin of… read more here.
Keywords: lam; cell; hox pbx; physiology ... See more keywords
Bioassay-Guided Isolation of Antiplasmodial Compounds from Hypericum lanceolatum Lam. (Hypericaceae) and Their Cytotoxicity and Molecular Docking
Sign Up to like & getrecommendations! Published in 2023 at "BioMed Research International"
DOI: 10.1155/2023/4693765
Abstract: In Cameroon, malaria is still the cause of several deaths yearly and leading to the continued search for new potent leads to fight against Plasmodium falciparum. Medicinal plants like Hypericum lanceolatum Lam. are introduced in… read more here.
Keywords: molecular docking; hypericum lanceolatum; guided isolation; bioassay guided ... See more keywords