Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-62105-1
Abstract: Specialized secretory cells, including keratinocytes in the last viable layers of mammalian epidermis, utilize lysosome-related organelles (LROs) to exocytose distinct cargoes vital for tissue function. Here, we demonstrate that the Flower isoform, hFWE4, a putative… read more here.
Keywords: epidermal barrier; flower dependent; dependent trafficking; hfwe4 ... See more keywords
Epidermal lamellar bodies, essential organelles for the skin barrier
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1597884
Abstract: Skin lamellar bodies are members of the Lysosome-Related-Organelle (LRO) family, characterized by specific features related to the skin’s primary function, i.e., protecting the body from external assaults while minimizing dehydration. In the uppermost living cell… read more here.
Keywords: bodies essential; essential organelles; lamellar bodies; skin barrier ... See more keywords