A Lamin-Associated Chromatin Model for Chromosome Organization.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.05.014
Abstract: We propose a simple model for chromatin organization based on the interaction of the chromatin fibers with lamin proteins along the nuclear membrane. Lamin proteins are known to be a major factor that influences chromatin… read more here.
Keywords: associated chromatin; model; organization; lamin associated ... See more keywords
Phosphorylated Lamin A/C in the Nuclear Interior Binds Active Enhancers Associated with Abnormal Transcription in Progeria.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.02.011
Abstract: LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the nuclear periphery. Mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown. We report that… read more here.
Keywords: nuclear interior; ps22 lamin; progeria; lamin binding ... See more keywords
Lamin A/C might be involved in the EMT signalling pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.04.040
Abstract: We have previously reported a heterogeneous expression pattern of the nuclear membrane protein lamin A/C in low- and high-Gleason score (GS) prostate cancer (PC) tissues, and we have now found that this change is not… read more here.
Keywords: emt met; might involved; expression; involved emt ... See more keywords
Understanding lamin proteins and their roles in aging and cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.026
Abstract: ABSTRACT The occurrence of cardiovascular diseases increases with age independent of other risk factors, and the percentage of senescent cells is significantly elevated in vascular cells at atherosclerotic sites. Patients with accelerated aging syndromes caused… read more here.
Keywords: roles aging; proteins roles; lamin proteins; cardiovascular diseases ... See more keywords
Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05912-z
Abstract: Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a… read more here.
Keywords: lamina associated; euchromatin lamin; associated domains; euchromatin ... See more keywords
Structural basis for lamin assembly at the molecular level
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11684-x
Abstract: Nuclear structure and function are governed by lamins, which are intermediate filaments that mostly consist of α-helices. Different lamin assembly models have been proposed based on low resolution and fragmented structures. However, their assembly mechanisms… read more here.
Keywords: structure; lamin assembly; molecular level; lamin ... See more keywords
Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1802811115
Abstract: Significance The lamin proteins are an important component of the nuclear scaffold. Abnormal lamins can cause a variety of disorders called laminopathies, one of which is the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Cells… read more here.
Keywords: hgps; cell lines; treatment; lamin proteins ... See more keywords
Interplay of lamin A and lamin B LADs on the radial positioning of chromatin
Sign Up to like & getrecommendations! Published in 2019 at "Nucleus"
DOI: 10.1080/19491034.2019.1570810
Abstract: ABSTRACT Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells. We show the existence of… read more here.
Keywords: radial positioning; chromatin; lamin lamin; lamin lads ... See more keywords
The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding
Sign Up to like & getrecommendations! Published in 2023 at "Nucleus"
DOI: 10.1080/19491034.2023.2180206
Abstract: Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a commonly used antibody (JOL-2) that binds the Lamin… read more here.
Keywords: lamin; density; cell density; density dependent ... See more keywords
Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-06-0393
Abstract: Tissue profiles and MSC transcriptomics separately indicate that LBR varies inversely with lamin-A,C. Such anti-correlations are recapitulated in MSC adipogenesis and osteogenesis as well as with matrix elasticity, knockdowns, overexpression, and myosin-II inhibition, which together… read more here.
Keywords: nuclear tension; increase nuclear; tension lamin; tissue ... See more keywords
Emerin prevents BAF-mediated aggregation of lamin A on chromosomes in telophase to allow nuclear membrane expansion and nuclear lamina formation
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-01-0007
Abstract: Several studies have suggested a role for the LEM-domain protein emerin and the DNA binding factor BAF in nuclear envelope reformation after mitosis, but the exact molecular mechanisms are not understood. Using HeLa cells deficient… read more here.
Keywords: lamin; aggregation; emerin; nuclear membrane ... See more keywords