Understanding lamin proteins and their roles in aging and cardiovascular diseases
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.026
Abstract: ABSTRACT The occurrence of cardiovascular diseases increases with age independent of other risk factors, and the percentage of senescent cells is significantly elevated in vascular cells at atherosclerotic sites. Patients with accelerated aging syndromes caused… read more here.
Keywords: roles aging; proteins roles; lamin proteins; cardiovascular diseases ... See more keywords
Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1802811115
Abstract: Significance The lamin proteins are an important component of the nuclear scaffold. Abnormal lamins can cause a variety of disorders called laminopathies, one of which is the premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS). Cells… read more here.
Keywords: hgps; cell lines; treatment; lamin proteins ... See more keywords