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   Articles with "lamina associated" as a keyword



Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains

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recommendations! Published in 2018 at "Nature Communications"

DOI: 10.1038/s41467-018-05912-z

Abstract: Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a… read more here.

Keywords: lamina associated; euchromatin lamin; associated domains; euchromatin ... See more keywords

Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-63244-1

Abstract: Chromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression. However, the strength of these interactions and their responsiveness to environmental cues remain unclear. Here, we develop… read more here.

Keywords: lamina associated; resolution imaging; chromatin lamina; biophysics ... See more keywords

Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth

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recommendations! Published in 2017 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddw368

Abstract: Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that has been implicated in striated muscle maintenance. Mutations in its gene have been linked to muscular dystrophy and cardiomyopathy. As germline… read more here.

Keywords: skeletal muscle; lamina associated; muscle; associated polypeptide ... See more keywords

Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage

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recommendations! Published in 2022 at "Genome Biology"

DOI: 10.1186/s13059-022-02662-6

Abstract: Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression, remains,… read more here.

Keywords: lineage; associated domains; differentiation; lamina ... See more keywords