Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
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DOI: 10.1038/s41467-018-05912-z
Abstract: Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a… read more here.
Keywords: lamina associated; euchromatin lamin; associated domains; euchromatin ... See more keywords
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth
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DOI: 10.1093/hmg/ddw368
Abstract: Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that has been implicated in striated muscle maintenance. Mutations in its gene have been linked to muscular dystrophy and cardiomyopathy. As germline… read more here.
Keywords: skeletal muscle; lamina associated; muscle; associated polypeptide ... See more keywords
Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage
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DOI: 10.1186/s13059-022-02662-6
Abstract: Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression, remains,… read more here.
Keywords: lineage; associated domains; differentiation; lamina ... See more keywords