Nuclear lamina integrity is required for proper spatial organization of chromatin in Drosophila
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09185-y
Abstract: How the nuclear lamina (NL) impacts on global chromatin architecture is poorly understood. Here, we show that NL disruption in Drosophila S2 cells leads to chromatin compaction and repositioning from the nuclear envelope. This increases… read more here.
Keywords: required proper; nuclear lamina; lamina integrity; integrity required ... See more keywords
Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Microbiology"
DOI: 10.1038/s41564-018-0285-5
Abstract: Tripartite motif (TRIM) proteins mediate antiviral host defences by either directly targeting viral components or modulating innate immune responses. Here we identify a mechanism of antiviral restriction in which a TRIM E3 ligase controls viral… read more here.
Keywords: nuclear lamina; lamina integrity; herpesvirus infection; trim43 ... See more keywords