Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2021.5992
Abstract: Importance Junctional epidermolysis bullosa (JEB) is an incurable blistering skin disorder with high infant mortality often caused by nonsense variants in the genes that encode laminin 332. Objective To evaluate the safety and outcomes following… read more here.
Keywords: treatment patients; epidermolysis bullosa; nonsense variants; laminin 332 ... See more keywords
Clinical and Serological Characterization of Orf-Induced Immunobullous Disease.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA dermatology"
DOI: 10.1001/jamadermatol.2022.0290
Abstract: Importance Ecthyma contagiosum, or orf, is a viral zoonotic infection caused by Poxviridae. Although human orf infection is considered to follow a self-limited course, various immunological reactions may be triggered, including immunobullous diseases. In the… read more here.
Keywords: disease; induced immunobullous; orf induced; laminin 332 ... See more keywords
Mechanism of anchorage-independency and tumor formation of cancer cells: possible involvement of cell membrane–bound laminin-332
Sign Up to like & getrecommendations! Published in 2019 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03114-7
Abstract: Cancer cells are characterized by anchorage-independency and tumor formation. Involvement of laminin-332 in the pathogenesis of cancer has also been reported. I present a theory that can explain these characteristics together. Proliferating keratinocytes in wound… read more here.
Keywords: cell; anchorage independency; cancer cells; laminin 332 ... See more keywords
Tissue substructure-specific deposition of the β3-containing laminin-332 in the biliary epithelium of human and mouse livers.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.01.104
Abstract: Laminin is a family of basement membrane proteins, whose selective and spatiotemporal expression profiles are linked to their various functions in development, maintenance, and functional regulation of different tissues. In the liver, α1-and α5-containing laminin… read more here.
Keywords: containing laminin; biliary epithelium; expression; laminin ... See more keywords
Laminin 332-Dependent YAP Dysregulation Depletes Epidermal Stem Cells in Junctional Epidermolysis Bullosa.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.055
Abstract: Laminin 332-deficient junctional epidermolysis bullosa (JEB) is a severe genetic skin disease. JEB is marked by epidermal stem cell depletion, the origin of which is unknown. We show that dysregulation of the YAP and TAZ… read more here.
Keywords: stem cells; jeb; yap; epidermal stem ... See more keywords
Molecular diagnosis of anti-laminin 332 (epiligrin) mucous membrane pemphigoid
Sign Up to like & getrecommendations! Published in 2018 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-018-0855-x
Abstract: BackgroundMucous membrane pemphigoid is a group of chronic subepithelial autoimmune blistering diseases that mainly affect mucous membranes. Laminin 332-specific autoantibodies are present in approximately 1/3 of the patients, being associated with an increased risk of… read more here.
Keywords: laminin 332; mucous membrane; membrane pemphigoid;
A basal cell defect promotes budding of prostatic intraepithelial neoplasia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.188177
Abstract: ABSTRACT Basal cells in a simple secretory epithelium adhere to the extracellular matrix (ECM), providing contextual cues for ordered repopulation of the luminal cell layer. Early high-grade prostatic intraepithelial neoplasia (HG-PIN) tissue has enlarged nuclei… read more here.
Keywords: basal; intraepithelial neoplasia; basal cell; prostatic intraepithelial ... See more keywords
Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.812627
Abstract: Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease characterized by autoantibodies against the basal membrane zone of skin and surface-close epithelia and predominant mucosal lesions. The oral cavity and conjunctivae are most frequently affected,… read more here.
Keywords: collagen; laminin 332; mucous membrane; anti laminin ... See more keywords
Anti-laminin 332 mucous membrane pemphigoid in a young woman treated with rituximab.
Sign Up to like & getrecommendations! Published in 2022 at "Dermatology online journal"
DOI: 10.5070/d328458517
Abstract: Mucous membrane pemphigoid, formerly known as cicatricial pemphigoid, is a rare and difficult-to-treat bullous disorder that occurs most commonly in older adults. We describe a 32-year-old woman who was diagnosed with anti-laminin 332 mucous membrane… read more here.
Keywords: laminin 332; mucous membrane; membrane pemphigoid; anti laminin ... See more keywords