Durability of the virological response after lamivudine discontinuation in lamivudine‐resistant patients with a complete virological response after lamivudine and adefovir combination therapy
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DOI: 10.1002/jmv.24616
Abstract: We investigated the durability of virological response after lamivudine (LAM) discontinuation in LAM‐resistant chronic hepatitis B (CHB) patients with complete virological response after LAM‐adefovir (ADV) combination therapy. We enrolled 58 patients switched to ADV monotherapy… read more here.
Keywords: virological response; combination; lamivudine; response lamivudine ... See more keywords
Why lamivudine assembles into double-stranded helices in crystals: salt heterosynthon versus base-pairing homosynthon
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DOI: 10.1039/c8ce00100f
Abstract: Here we were interested in obtaining a better understanding of the competition between the salt heterosynthon and the base-pairing homosynthon formed by the anti-HIV drug lamivudine in the presence of strong acids. Even though the… read more here.
Keywords: pairing homosynthon; lamivudine duplexes; base pairing; lamivudine ... See more keywords
An up-to-date evaluation of dolutegravir/abacavir/lamivudine for the treatment of HIV
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Pharmacotherapy"
DOI: 10.1080/14656566.2022.2029409
Abstract: ABSTRACT Introduction There are more than 30 agents available for the treatment of HIV with guidelines shifting toward integrase strand transfer inhibitors (INSTIs) as part of first line therapy. The fixed dose combination of dolutegravir… read more here.
Keywords: treatment hiv; hiv; treatment; dolutegravir ... See more keywords
Optimization of the strength of the efavirenz/lamivudine/abacavir fixed-dose combination for paediatric patients
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DOI: 10.1093/jac/dkw444
Abstract: Background Child-friendly, low-cost, solid, oral fixed-dose combinations (FDCs) of efavirenz with lamivudine and abacavir are urgently needed to improve clinical management and drug adherence for children. Methods Data were pooled from several clinical trials and… read more here.
Keywords: abacavir fixed; lamivudine; lamivudine abacavir; fixed dose ... See more keywords
Recommended First-Line Antiretroviral Therapy Regimens and Risk of Diabetes Mellitus in HIV-Infected Adults in Resource-Limited Settings
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DOI: 10.1093/ofid/ofz298
Abstract: Abstract Objective The use of some antiretroviral drugs has been associated with a higher risk of diabetes mellitus (DM) in HIV-infected patients, but the risk associated with antiretroviral drug combinations remains unclear. We investigated the… read more here.
Keywords: risk; first line; lamivudine; zidovudine lamivudine ... See more keywords
Lamivudine therapy during the second vs the third trimester for preventing transmission of chronic hepatitis B
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DOI: 10.1111/jvh.12640
Abstract: There are little data on the timing of initiating lamivudine therapy for preventing transmission of hepatitis B in highly viremic mothers. Between May 2008 and January 2015, we retrospectively enrolled mothers with HBV DNA >6… read more here.
Keywords: second third; transmission; hepatitis; third trimester ... See more keywords
Tenofovir versus lamivudine followed by tenofovir in severe exacerbation of hepatitis B: a randomized controlled study.
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DOI: 10.1128/aac.01664-21
Abstract: Spontaneous severe acute exacerbation (SAE) is not uncommon in the natural history of chronic hepatitis B (CHB). Lamivudine (LAM) had the advantages of low price, quick onset, good efficacy and no drug resistance within 24… read more here.
Keywords: lamivudine; exacerbation; lam weeks; study ... See more keywords
Efavirenz reduces renal excretion of lamivudine in rats by inhibiting organic cation transporters (OCT, Oct) and multidrug and toxin extrusion proteins (MATE, Mate)
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DOI: 10.1371/journal.pone.0202706
Abstract: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor used in first-line combination antiretroviral therapy (cART). It is usually administered with nucleoside reverse transcriptase inhibitors (NRTI), many of which are substrates of OCT uptake solute carriers… read more here.
Keywords: efavirenz; mate; mate mate; lamivudine ... See more keywords
Putative Repurposing of Lamivudine, a Nucleoside/Nucleotide Analogue and Antiretroviral to Improve the Outcome of Cancer and COVID-19 Patients
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DOI: 10.3389/fonc.2021.664794
Abstract: Lamivudine, also widely known as 3TC belongs to a family of nucleotide/nucleoside analogues of cytidine or cytosine that inhibits the Reverse Transcriptase (RT) of retroviruses such as HIV. Lamivudine is currently indicated in combination with… read more here.
Keywords: repurposing lamivudine; hepatitis; covid; lamivudine ... See more keywords
Quality by Design Optimization of Cold Sonochemical Synthesis of Zidovudine-Lamivudine Nanosuspensions
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DOI: 10.3390/pharmaceutics12040367
Abstract: Lamivudine (3TC) and zidovudine (AZT) are antiviral agents used to manage HIV/AIDS infection. The compounds require frequent dosing, exhibit unpredictable bioavailability and a side effect profile that includes hepato- and haema-toxicity. A novel pseudo one-solvent… read more here.
Keywords: zidovudine; nano crystals; lamivudine; spectroscopy ... See more keywords
Comparison of the Effects of Three Dual-Nucleos(t)ide Reverse Transcriptase Inhibitor Backbones on Placenta Mitochondria Toxicity and Oxidative Stress Using a Mouse Pregnancy Model
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DOI: 10.3390/pharmaceutics14051063
Abstract: Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) are the backbone of HIV antiretroviral therapy (ART). ART use in pregnancy has been associated with adverse birth outcomes, in part due to NRTI-induced mitochondrial toxicity. Direct comparison on the… read more here.
Keywords: lamivudine; oxidative stress; toxicity; pregnancy ... See more keywords