Effect of lamotrigine on epilepsy‐induced cognitive impairment and hippocampal neuronal apoptosis in pentylenetetrazole‐kindled animal model
Sign Up to like & getrecommendations! Published in 2017 at "Synapse"
DOI: 10.1002/syn.21945
Abstract: Lamotrigine (LTG) is a broad‐spectrum antiepileptic drug that is widely used in clinic. However, the effect of LTG on cognition and neurodegeneration during epilepsy treatment remains controversial. In this study, we compared the cognitive effects… read more here.
Keywords: epilepsy; animal model; effect; kindled animal ... See more keywords
Spider diagram and Analytical GREEnness metric approach for assessing the greenness of quantitative 1H-NMR determination of lamotrigine: Taguchi method based optimization
Sign Up to like & getrecommendations! Published in 2021 at "Chemometrics and Intelligent Laboratory Systems"
DOI: 10.1016/j.chemolab.2020.104198
Abstract: Abstract An optimized eco-friendly quantitative proton nuclear magnetic resonance (1H NMR) method was developed for determination of lamotrigine. Taguchi method was utilized as a chemometric approach for the first time to optimize different NMR experimental… read more here.
Keywords: lamotrigine; method; approach; determination lamotrigine ... See more keywords
Trend Analysis of the Utilization of Antiepileptic Drugs in Pregnant Women With Epilepsy
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Therapeutics"
DOI: 10.1016/j.clinthera.2017.05.255
Abstract: Aim: Little is known about the consumption of antiepileptic drugs in pregnancy in the Czech Republic, particularly for newer agents. In our previous paper, we discussed long-term trends in the utilization of antiepileptic drugs during… read more here.
Keywords: carbamazepine; pregnant women; valproic acid; antiepileptic drugs ... See more keywords
Pharmacokinetics in Plants: Carbamazepine and Its Interactions with Lamotrigine.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b01682
Abstract: Carbamazepine and lamotrigine prescribed antiepileptic drugs are highly persistent in the environment and were detected in crops irrigated with reclaimed wastewater. This study reports pharmacokinetics of the two drugs and their metabolites in cucumber plants… read more here.
Keywords: carbamazepine; plants carbamazepine; root; pharmacokinetics plants ... See more keywords
Development of magnetic molecularly imprinted polymers with double templates for the rapid and selective determination of carbamazepine and lamotrigine in serum
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra09306a
Abstract: A dual-template magnetic molecularly imprinted polymer (Dt-MMIP) with a specific recognition capability for carbamazepine (CBZ) and lamotrigine (LTG) was synthesized using methacrylic acid as a functional monomer, and ethylene glycol dimethylmethacrylate as a cross-linking agent.… read more here.
Keywords: rapid selective; molecularly imprinted; serum; magnetic molecularly ... See more keywords
What’s Going on with Lamotrigine (Lamictal)? An Updated Look at the Popular Medication for Bipolar Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Issues in Mental Health Nursing"
DOI: 10.1080/01612840.2022.2104042
Abstract: Lamotrigine, also frequently referred to by its brand name Lamictal, is one of the most commonly used anticonvulsant medications for the treatment of bipolar disorder. The medication is popular because it has a long-established reputation… read more here.
Keywords: medication; safety; disorder; bipolar disorder ... See more keywords
Formulation optimization of smart thermosetting lamotrigine loaded hydrogels using response surface methodology, box benhken design and artificial neural networks
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2020.1791163
Abstract: Abstract The aim of this research was to develop lamotrigine containing thermosetting hydrogel for intranasal administration to manage and treat generalized epilepsy. Thermosetting hydrogels were prepared using different ratios of poloxamer 407 (L127), poloxamer 188… read more here.
Keywords: methodology; formulation optimization; box; lamotrigine ... See more keywords
Short‐ and long‐term complications of in utero exposure to lamotrigine
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Clinical Pharmacology"
DOI: 10.1111/bcp.13437
Abstract: AIMS The present study evaluates the effect of antenatal lamotrigine exposure, on short- and long-term paediatric outcome. METHODS The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary… read more here.
Keywords: term; long term; term complications; exposure ... See more keywords
Impact of cannabidiol and lamotrigine on parameters of action potentials in sciatic nerves of frogs
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733999
Abstract: Cannabidiol causes inhibitory effects on sodium channels, but its action on nerve impulses is not understood. Lamotrigine blocks the nerve impulses, however, it is not known if this action is of extracellular or intracellular origin.… read more here.
Keywords: cannabidiol; cluster; action; physiology ... See more keywords
Lamictal® and Hemophagocytic Lymphohistiocytosis (HLH)
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DOI: 10.1182/blood-2019-127531
Abstract: Introduction: Hemophagocytic lymphohisticoytosis (HLH) is a life threatening disorder resulting from uncontrolled macrophage activation. HLH may be primary or associated with active infection, autoimmune disorder or neoplasia. In a recently reported national surveillance report from… read more here.
Keywords: treatment; hlh; report; day ... See more keywords
Epilepsy-Induced High Affinity Blockade of the Cardiac Sodium Current INa by Lamotrigine; A Potential for Acquired Arrythmias
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15101208
Abstract: Lamotrigine is widely prescribed to treat bipolar neurological disorder and epilepsy. It exerts its antiepileptic action by blocking voltage-gated sodium channels in neurons. Recently, the US Food and Drug Administration issued a warning on the… read more here.
Keywords: sodium; current ina; sodium current; cardiac sodium ... See more keywords