Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms
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DOI: 10.1371/journal.pone.0235815
Abstract: Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs.… read more here.
Keywords: developability; transgenic animal; animal platforms; platforms complementary ... See more keywords
Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010625
Abstract: Lassa virus (LASV) cell entry is mediated by the interaction of the virus glycoprotein complex (GPC) with alpha-dystroglycan at the cell surface followed by binding to LAMP1 in late endosomes. However, LAMP1 is not absolutely… read more here.
Keywords: fusion; lamp1; dilation; lasv fusion ... See more keywords
Prognostic value of LAMP1 in surgically resected esophageal squamous cell carcinoma
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DOI: 10.21037/20165
Abstract: Background: The 5-year survival rate of esophageal squamous cell carcinoma (ESCC) is very low. It has been confirmed that lysosomal associated membrane protein 1 (LAMP1) plays an important role in the invasion and metastasis of… read more here.
Keywords: cell carcinoma; squamous cell; expression; lamp1 ... See more keywords
Lamp1 Deficiency Enhances Sensitivity to α-Synuclein and Oxidative Stress in Drosophila Models of Parkinson Disease
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DOI: 10.3390/ijms232113078
Abstract: Parkinson disease (PD) is a common neurodegenerative condition affecting people predominantly at old age that is characterized by a progressive loss of midbrain dopaminergic neurons and by the accumulation of α-synuclein-containing intraneuronal inclusions known as… read more here.
Keywords: lamp1; parkinson disease; oxidative stress; drosophila ... See more keywords