Landscape of Germline and Somatic Mitochondrial DNA Mutations in Pediatric Malignancies.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-2220
Abstract: Little is known about the spectrum of mitochondrial DNA (mtDNA) mutations across pediatric malignancies. In this study, we analyzed matched tumor and normal whole genome sequencing data from 616 pediatric patients with hematopoietic malignancies, solid… read more here.
Keywords: landscape germline; pediatric malignancies; mtdna; mitochondrial dna ... See more keywords
Changing the landscape of germline testing in patients with pancreatic adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.676
Abstract: 676Background: Results from the POLO trial demonstrated the benefits of PARP inhibition in patients (pts) with germline BRCA-mutated metastatic pancreatic cancer (PC). In 2018, ASCO and NCCN update... read more here.
Keywords: testing patients; landscape germline; pancreatic adenocarcinoma; germline testing ... See more keywords