Understanding the impact of chemotherapy on the immune landscape of high-grade serous ovarian cancer
Sign Up to like & getrecommendations! Published in 2022 at "Gynecologic Oncology Reports"
DOI: 10.1016/j.gore.2022.100926
Abstract: Highlights • Neoadjuvant chemotherapy induces heterogeneous changes in the tumor microenvironment.• Macrophages are a significant component of the TME PD-L1 expression enriched in a subset of patients.• Alteration in T cell ratios after chemotherapy indicate… read more here.
Keywords: chemotherapy immune; chemotherapy; impact chemotherapy; understanding impact ... See more keywords
Potential landscape of high dimensional nonlinear stochastic dynamics with large noise
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15889-2
Abstract: Quantifying stochastic processes is essential to understand many natural phenomena, particularly in biology, including the cell-fate decision in developmental processes as well as the genesis and progression of cancers. While various attempts have been made… read more here.
Keywords: high dimensional; potential landscape; dimensional nonlinear; landscape high ... See more keywords
Abstract 3000: Defining the subclonal landscape of high-risk neuroblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3000
Abstract: We recently showed that relapsed neuroblastoma (NB) tumors harbor an increased somatic mutational burden, enriched for ALK or RAS-MAPK activating lesions, nominating targeted therapeutic strategies for a condition that is largely incurable. We also showed… read more here.
Keywords: risk; defining subclonal; high risk; landscape high ... See more keywords