Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.10.029
Abstract: The dynamic transcriptional regulation and interactions of human germlines and surrounding somatic cells during folliculogenesis remain unknown. Using RNA sequencing (RNA-seq) analysis of human oocytes and corresponding granulosa cells (GCs) spanning five follicular stages, we… read more here.
Keywords: transcriptome landscape; folliculogenesis reveals; human folliculogenesis; folliculogenesis ... See more keywords
Digging Deeper to Chart the Landscape of Human Brain Development
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.03.030
Abstract: How does brain system organization evolve during development? Cui et al. (2020) combine big and higher-precision fMRI data to find that maturational processes and cognitive ability track individual differences in the refinement of borders between brain… read more here.
Keywords: digging deeper; chart landscape; landscape human; brain ... See more keywords
The mutational landscape of human somatic and germline cells.
Sign Up to like & getrecommendations! Published in 2021 at "Nature"
DOI: 10.1038/s41586-021-03822-7
Abstract: Over the course of an individual's lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two… read more here.
Keywords: mutational landscape; human somatic; landscape; cell types ... See more keywords
The neuropeptide landscape of human prefrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123146119
Abstract: Significance The neuropeptide system encompasses the most diverse family of neurotransmitters, but their expression, cellular localization, and functional role in the human brain have received limited attention. Here, we study human postmortem samples from prefrontal… read more here.
Keywords: landscape human; neuropeptide landscape; prefrontal cortex; human prefrontal ... See more keywords
The somatic mutation landscape of the human body
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology"
DOI: 10.1186/s13059-019-1919-5
Abstract: BackgroundSomatic mutations in healthy tissues contribute to aging, neurodegeneration, and cancer initiation, yet they remain largely uncharacterized.ResultsTo gain a better understanding of the genome-wide distribution and functional impact of somatic mutations, we leverage the genomic… read more here.
Keywords: human body; mutation landscape; somatic mutation; tissue ... See more keywords
Transcriptional landscape of human cancers
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15837
Abstract: The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively explored. However, the related exploration based on transcriptome data is lacking. In this study we explored… read more here.
Keywords: cancer types; human cancers; transcriptional landscape; cancer ... See more keywords