Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing
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DOI: 10.18632/oncotarget.18678
Abstract: Mixed adenoneuroendocrine carcinoma (MANEC) in the esophagus is an infrequent but highly malignant cancer with few known genomic alterations. We conducted whole-exome sequencing and whole-genome SNP genotyping for 4-6 tumor subregions and 5-6 adjacent normal… read more here.
Keywords: tumor; mutation landscape; heterogeneity; intra tumor ... See more keywords