The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Sign Up to like & getrecommendations! Published in 2018 at "Nature Medicine"
DOI: 10.1038/nm.4439
Abstract: We present the molecular landscape of pediatric acute myeloid leukemia (AML) and characterize nearly 1,000 participants in Children's Oncology Group (COG) AML trials. The COG–National Cancer Institute (NCI) TARGET AML initiative assessed cases by whole-genome,… read more here.
Keywords: myeloid leukemia; molecular landscape; acute myeloid; pediatric acute ... See more keywords
The genomic landscape of pediatric cancers: Implications for diagnosis and treatment
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aaw3535
Abstract: The past decade has witnessed a major increase in our understanding of the genetic underpinnings of childhood cancer. Genomic sequencing studies have highlighted key differences between pediatric and adult cancers. Whereas many adult cancers are… read more here.
Keywords: cancers implications; implications diagnosis; diagnosis treatment; pediatric cancers ... See more keywords
Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort
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DOI: 10.3324/haematol.2018.204974
Abstract: Novel biological subtypes and clinically important genetic aberrations (druggable lesions, prognostic factors) have been described in B-other acute lymphoblastic leukemia (ALL) during the last decade; however, due to a lack of studies on unselected cohorts,… read more here.
Keywords: lymphoblastic leukemia; acute lymphoblastic; leukemia; pediatric acute ... See more keywords
Molecular Landscape of Pediatric Thyroid Cancer: A Review
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DOI: 10.3390/diagnostics12123136
Abstract: Thyroid carcinomas (TC) are rare in the pediatric population; however, they constitute the most common endocrine malignancy. Despite some similarities with adult carcinomas, they have distinct clinical behavior and responses to therapy due to their… read more here.
Keywords: molecular landscape; cancer review; thyroid cancer; landscape pediatric ... See more keywords