A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.07.006
Abstract: Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped… read more here.
Keywords: mutant cancers; therapeutic cooperativity; landscape therapeutic; cancers reveals ... See more keywords
The Evolving AML Genomic Landscape: Therapeutic Implications.
Sign Up to like & getrecommendations! Published in 2020 at "Current cancer drug targets"
DOI: 10.2174/1568009620666200424150321
Abstract: Improved understanding of the genomic and molecular landscape of acute myeloid leukemia (AML) has resulted in significant evolution of our understanding of AML biology and allows refined prognostication for those receiving standard combination chemotherapy induction.… read more here.
Keywords: landscape therapeutic; evolving aml; aml genomic; therapeutic implications ... See more keywords