Clinical outcomes and prognostic risk factors of Langerhans cell histiocytosis in children: Results from the BCH‐LCH 2014 protocol study
Sign Up to like & getrecommendations! Published in 2023 at "American Journal of Hematology"
DOI: 10.1002/ajh.26829
Abstract: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm mainly affecting young children. This study aimed to evaluate the outcomes of 449 pediatric patients enrolled in the BCH‐LCH 2014 study. 52.6% of patients were classified… read more here.
Keywords: langerhans cell; lch 2014; bch lch; risk ... See more keywords
Efficacy of denosumab monotherapy among adults with Langerhans cell histiocytosis: A prospective clinical trial.
Sign Up to like & getrecommendations! Published in 2023 at "American journal of hematology"
DOI: 10.1002/ajh.26936
Abstract: This phase IIb clinical trial evaluated the efficacy of a bimonthly treatment schedule (Q8W) with 4 subcutaneous doses of denosumab 120 mg among adults with Langerhans cell histiocytosis needing first-line systemic therapy for either multifocal single-system… read more here.
Keywords: langerhans cell; among adults; disease; clinical trial ... See more keywords
CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH‐associated neurodegeneration and mass lesions
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DOI: 10.1002/cncr.31348
Abstract: Central nervous system Langerhans cell histiocytosis (CNS‐LCH) brain involvement may include mass lesions and/or a neurodegenerative disease (LCH‐ND) of unknown etiology. The goal of this study was to define the mechanisms of pathogenesis that drive… read more here.
Keywords: langerhans cell; cell histiocytosis; mass lesions; lch ... See more keywords
Diagnosis of Langerhans cell histiocytosis on cytological examination of cerebrospinal fluid: Report of the first case
Sign Up to like & getrecommendations! Published in 2022 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25040
Abstract: Langerhans cell histiocytosis (LCH) is a disease of unknown etiology characterized by a proliferation of histiocytic cells resembling dendritic Langerhans cells. LCH can be unifocal or multifocal, with one‐ or many‐organ involvement. The serous fluids… read more here.
Keywords: langerhans cell; diagnosis; cerebrospinal fluid; case ... See more keywords
Classic cytomorphological features of Langerhans cell histiocytosis with osseous involvement
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DOI: 10.1002/dc.25050
Abstract: Langerhans cell histiocytosis (LCH) is a rare condition characterized by proliferation of pathologic Langerhans cells. It is usually diagnosed during the first three decades of life, and has a predilection for males. Even though the… read more here.
Keywords: langerhans cell; cytomorphological features; classic cytomorphological; osseous involvement ... See more keywords
Langerhans cell histiocytosis: A diagnostic challenge on thyroid fine needle aspiration cytology
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DOI: 10.1002/dc.25094
Abstract: Thyroid gland involvement by Langerhans cell histiocytosis (LCH) is extremely rare. A 28‐year‐old woman with a history of polyuria, polydipsia and amenorrhoea presented with a diffuse thyroid swelling of 2 months duration. Clinical diagnosis was diabetes… read more here.
Keywords: langerhans cell; fine needle; aspiration cytology; needle aspiration ... See more keywords
Analysis of the BRAFV600E mutation in 19 cases of Langerhans cell histiocytosis in Japan
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DOI: 10.1002/hon.2293
Abstract: Langerhans cell histiocytosis (LCH) is a rare disease characterized by clonal proliferation of CD1a‐ and CD207 (langerin)‐positive dendritic cells. Mutated BRAF (p.V600E) is observed in histiocyte‐related diseases and dendritic cell‐related diseases, including LCH. BRAFV600E is… read more here.
Keywords: langerhans cell; analysis; brafv600e mutation; cell histiocytosis ... See more keywords
Aggressive Langerhans cell histiocytosis transformation of T cell acute lymphoblastic leukemia detected on 18F-FDG PET/CT
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DOI: 10.1007/s00259-020-04872-1
Abstract: A 12-year-old boy with clinical history of T cell acute lymphoblastic leukemia (T-ALL) 10 months ago presented with multiple palpable and enlarged left cervical lymph nodes, splenomegaly, and fatigue for 1 month. Bonemarrow biopsy result… read more here.
Keywords: langerhans cell; cell acute; fdg pet; transformation ... See more keywords
Molecular analysis of BRAF V600E mutation in multiple nodules of pulmonary Langerhans cell histiocytosis
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DOI: 10.1007/s00428-017-2092-4
Abstract: Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking-related histiocytic disorder with variable clinical symptoms. Like in other non-pulmonary Langerhans cell proliferations, PLCH has recently been shown to harbour BRAF V600E mutations in a significant… read more here.
Keywords: langerhans cell; braf v600e; braf; pulmonary langerhans ... See more keywords
Periodontal manifestations of Langerhans cell histiocytosis: a systematic review
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DOI: 10.1007/s00784-021-03873-0
Abstract: Objectives To explore the evidence of periodontal manifestations and treatment modalities in patients with Langerhans cell histiocytosis (LCH). Material and methods A systematic literature search was performed and the criteria for PRISMA and risk of… read more here.
Keywords: langerhans cell; manifestations langerhans; periodontal findings; periodontal manifestations ... See more keywords
Unisystem Langerhans cell histiocytosis in maxillofacial region in pediatrics: comprehensive and systematic review
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DOI: 10.1007/s10006-021-00949-9
Abstract: The study aimed to identify, enlist, and analyze cases of unisystem LCH in the maxillofacial pediatric population to understand the clinical presentation and encourage the consideration of this rare disease in the differential diagnosis. Langerhans… read more here.
Keywords: langerhans cell; maxillofacial region; cell histiocytosis; review ... See more keywords