Yeast Sec14‐like lipid transfer proteins Pdr16 and Pdr17 bind and transfer the ergosterol precursor lanosterol in addition to phosphatidylinositol
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14558
Abstract: Yeast Sec14‐like phosphatidylinositol transfer proteins (PITPs) contain a hydrophobic cavity capable of accepting a single molecule of phosphatidylinositol (PI) or another molecule in a mutually exclusive manner. We report here that two yeast Sec14 family… read more here.
Keywords: transfer proteins; transfer; lanosterol; phosphatidylinositol ... See more keywords
Lanosterol disrupts the aggregation of amyloid-β peptides.
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DOI: 10.1021/acschemneuro.9b00285
Abstract: Lanosterol, an amphipathic molecule, was discovered only very recently to effectively hinder the aggregation of the lens proteins and dissolve the extremely stable fibrillar aggregates in cataracts. Here, we combined computational and experimental approaches to… read more here.
Keywords: aggregation; peptide; lanosterol disrupts; aggregation amyloid ... See more keywords
Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts
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DOI: 10.1038/s41598-019-44676-4
Abstract: The paradigm that cataracts are irreversible and that vision from cataracts can only be restored through surgery has recently been challenged by reports that oxysterols such as lanosterol and 25-hydroxycholesterol can restore vision by binding… read more here.
Keywords: oxysterols lanosterol; lanosterol hydroxycholesterol; failure oxysterols; lanosterol ... See more keywords
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery
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DOI: 10.1128/aac.01131-18
Abstract: Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has… read more here.
Keywords: azole drugs; full length; fungal pathogens; discovery ... See more keywords
Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
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DOI: 10.12688/f1000research.125645.2
Abstract: Mycoses or fungal infections are general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in Fungi and the incidence of azole antibiotic resistance in the… read more here.
Keywords: demethylase; phytochemical profiling; review; lanosterol ... See more keywords