In Vitro and In Silico Analysis of Ascorbic Acid Towards Lanosterol 14-α-Demethylase Enzyme of Fluconazole-Resistant Candida albicans
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DOI: 10.1007/s00284-020-02269-9
Abstract: Antibiotic resistance is one of the major concerns and the biggest threats to the world population. The incidents of antibiotic resistance in Candida spp. were frequently recorded. In the present investigation, antifungal potential of ascorbic… read more here.
Keywords: analysis; silico analysis; ascorbic acid; vitro silico ... See more keywords
Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase
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DOI: 10.1128/aac.02242-17
Abstract: ABSTRACT Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the membrane-bound cytochrome P450 monooxygenase lanosterol 14α-demethylase (CYP51; Erg11p). Mutations in CYP51 can render the… read more here.
Keywords: saccharomyces cerevisiae; lanosterol demethylase; resistance; resistance mutations ... See more keywords
Synthesis, Molecular Docking Studies, and Antifungal Activity Evaluation of New Benzimidazole-Triazoles as Potential Lanosterol 14α-Demethylase Inhibitors
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DOI: 10.1155/2017/9387102
Abstract: Due to anticandidal importance of azole compounds, a new series of benzimidazole-triazole derivatives (5a–5s) were designed and synthesized as ergosterol inhibitors. The chemical structures of the target compounds were characterized by spectroscopic methods. The final… read more here.
Keywords: lanosterol demethylase; docking studies; candida; antifungal activity ... See more keywords
Insilico prediction and pharmacokinetic studies on glucosinolates as potential drug and key inhibitor molecule for lanosterol-14α-demethylase, fungal membrane biosynthesis.
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DOI: 10.2174/1570163819666220615142933
Abstract: BACKGROUND Glucosinolates (b-thioglucoside-N-hydroxysulfates) are a water-soluble organic anion with sulfur- and nitrogen-containing glycosides which are found in abundance in Cruciferous plants. Ergosterol (ERG13) lanosterol-14α-demethylase protein has been targeted for inihibition studies as a key regulator… read more here.
Keywords: demethylase; lanosterol demethylase; membrane biosynthesis; fungal membrane ... See more keywords
Novel nucleosides as potential inhibitors of fungal lanosterol 14α-demethylase: an in vitro and in silico study.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0014
Abstract: Aim: The global burden of fungal infections has transitioned from a case-specific observation to a major cause of high human mortality. Therefore, novel compounds with innovative methodologies need to be synthesized and evaluated for their… read more here.
Keywords: potential inhibitors; nucleosides potential; fungal lanosterol; novel nucleosides ... See more keywords