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Published in 2020 at "Current Microbiology"
DOI: 10.1007/s00284-020-02269-9
Abstract: Antibiotic resistance is one of the major concerns and the biggest threats to the world population. The incidents of antibiotic resistance in Candida spp. were frequently recorded. In the present investigation, antifungal potential of ascorbic…
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Keywords:
analysis;
silico analysis;
ascorbic acid;
vitro silico ... See more keywords
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Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02242-17
Abstract: ABSTRACT Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the membrane-bound cytochrome P450 monooxygenase lanosterol 14α-demethylase (CYP51; Erg11p). Mutations in CYP51 can render the…
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Keywords:
saccharomyces cerevisiae;
lanosterol demethylase;
resistance;
resistance mutations ... See more keywords
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Published in 2017 at "Journal of Chemistry"
DOI: 10.1155/2017/9387102
Abstract: Due to anticandidal importance of azole compounds, a new series of benzimidazole-triazole derivatives (5a–5s) were designed and synthesized as ergosterol inhibitors. The chemical structures of the target compounds were characterized by spectroscopic methods. The final…
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Keywords:
lanosterol demethylase;
docking studies;
candida;
antifungal activity ... See more keywords
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Published in 2022 at "Current drug discovery technologies"
DOI: 10.2174/1570163819666220615142933
Abstract: BACKGROUND Glucosinolates (b-thioglucoside-N-hydroxysulfates) are a water-soluble organic anion with sulfur- and nitrogen-containing glycosides which are found in abundance in Cruciferous plants. Ergosterol (ERG13) lanosterol-14α-demethylase protein has been targeted for inihibition studies as a key regulator…
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Keywords:
demethylase;
lanosterol demethylase;
membrane biosynthesis;
fungal membrane ... See more keywords
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Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2019-0014
Abstract: Aim: The global burden of fungal infections has transitioned from a case-specific observation to a major cause of high human mortality. Therefore, novel compounds with innovative methodologies need to be synthesized and evaluated for their…
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Keywords:
potential inhibitors;
nucleosides potential;
fungal lanosterol;
novel nucleosides ... See more keywords