Lapachol is a novel ribosomal protein S6 kinase 2 inhibitor that suppresses growth and induces intrinsic apoptosis in esophageal squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6415
Abstract: Lapachol is a 1,4‐naphthoquinone that is isolated from the Bignoniaceae family. It has been reported to exert anti‐inflammatory, antibacterial, and anticancer activities. However, the anticancer activity of lapachol and its molecular mechanisms against esophageal squamous… read more here.
Keywords: protein; inhibitor; cell; escc cells ... See more keywords
Understanding the fragmentation mechanisms of methoxy-, mesyl-, and tosyl-lapachol derivatives by computational chemistry and mass spectrometry analysis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Mass Spectrometry"
DOI: 10.1016/j.ijms.2016.11.012
Abstract: Abstract Quinone derivatives are promising anticancer, antimalarial, and antileishmanial drug candidates. Lapachol is the main natural quinonoid compound studied to date. The synthesis of lapachol (2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone) derivatives can help characterization of these compounds in biological… read more here.
Keywords: spectrometry; mass spectrometry; chemistry; lapachol ... See more keywords
Lapachol in the Design of a New Ruthenium(II)-Diphosphine Complex as a Promising Anticancer Metallodrug.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111289
Abstract: The preparation of two new Ru(II)/diphosphine complexes containing Lapachol (Lap) and Lawsone (Law): (1) [Ru(Lap)(dppm)2]PF6 and (2) [Ru(Law)(dppm)2]PF6, where dppm = bis(diphenylphosphino)methane, is reported here. The complexes were synthetized and fully characterized by elemental analyses, molar conductivity,… read more here.
Keywords: mda 231; new ruthenium; diphosphine; lapachol ... See more keywords
In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol DERIVATES.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104181
Abstract: The aim of this research was to investigate the pharmacological properties of 2-(2-Hydroxyethylamine)-3-(3-methyl-2-butenyl)-1,4-dihydro-1,4-naphthalenedione, 2-(2-Hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone and 2-(3-Hydroxy-propylamine)-3-(3-methyl-2-butenyl)-[1,4]naphthoquinone using computational prediction models, in addition to evaluating the in vitro antibacterial and modulatory activity of these compounds against… read more here.
Keywords: antibacterial modulatory; lapachol; modulatory activity; lapachol lapachol ... See more keywords
Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol
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DOI: 10.1016/j.poly.2019.03.010
Abstract: Abstract Mixed ligand complexes [Cu(phen)(Lap)2] (1) and [Co(dppeO)(Lap)2] (2) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl2] or [Co(dppe)Cl2] in the presence of Et3N. Complexes (1) and (2) were fully characterized by X-ray… read more here.
Keywords: synthesis characterization; ligand complexes; lapachol; mixed ligand ... See more keywords
Development of long-circulating lapachol nanoparticles: formation, characterization, pharmacokinetics, distribution and cytotoxicity
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DOI: 10.1039/d0ra05752e
Abstract: Lapachol is an active compound for the treatment of malignant brain glioma. However, its physicochemical properties limit its clinical application. The purpose of this study is to develop a nano-drug delivery system (LPC-LP) loaded with… read more here.
Keywords: lpc; glioma; lapachol; brain ... See more keywords
Synthesis and evaluation of isoxazole derivatives of lapachol as inhibitors of pyruvate kinase M2
Sign Up to like & getrecommendations! Published in 2024 at "Synthetic Communications"
DOI: 10.1080/00397911.2024.2383952
Abstract: Abstract Lapachol is a proven anticancer medication ingredient that has been removed from the market due to its toxicity, but cannot disregard its therapeutic properties. Aiming to search for potent anticancer derivative of lapachol with… read more here.
Keywords: derivatives lapachol; lapachol; synthesis evaluation; evaluation isoxazole ... See more keywords
Chitosan Nanoparticles Enhance the Antiproliferative Effect of Lapachol in Urothelial Carcinoma Cell Lines
Sign Up to like & getrecommendations! Published in 2025 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics17070868
Abstract: Backgroud/Objectives: Lapachol is a naturally occurring prenylated naphthoquinone with antiproliferative effects. However, its clinical application remains limited due to several factors, including poor water solubility, low bioavailability, and adverse effects. The development of chitosan-based nanoparticles… read more here.
Keywords: cell lines; enhance antiproliferative; lapachol; chitosan nanoparticles ... See more keywords