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Published in 2019 at "Phytotherapy Research"
DOI: 10.1002/ptr.6415
Abstract: Lapachol is a 1,4‐naphthoquinone that is isolated from the Bignoniaceae family. It has been reported to exert anti‐inflammatory, antibacterial, and anticancer activities. However, the anticancer activity of lapachol and its molecular mechanisms against esophageal squamous…
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Keywords:
protein;
inhibitor;
cell;
escc cells ... See more keywords
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Published in 2017 at "International Journal of Mass Spectrometry"
DOI: 10.1016/j.ijms.2016.11.012
Abstract: Abstract Quinone derivatives are promising anticancer, antimalarial, and antileishmanial drug candidates. Lapachol is the main natural quinonoid compound studied to date. The synthesis of lapachol (2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone) derivatives can help characterization of these compounds in biological…
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Keywords:
spectrometry;
mass spectrometry;
chemistry;
lapachol ... See more keywords
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Published in 2020 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2020.111289
Abstract: The preparation of two new Ru(II)/diphosphine complexes containing Lapachol (Lap) and Lawsone (Law): (1) [Ru(Lap)(dppm)2]PF6 and (2) [Ru(Law)(dppm)2]PF6, where dppm = bis(diphenylphosphino)methane, is reported here. The complexes were synthetized and fully characterized by elemental analyses, molar conductivity,…
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Keywords:
mda 231;
new ruthenium;
diphosphine;
lapachol ... See more keywords
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Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104181
Abstract: The aim of this research was to investigate the pharmacological properties of 2-(2-Hydroxyethylamine)-3-(3-methyl-2-butenyl)-1,4-dihydro-1,4-naphthalenedione, 2-(2-Hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone and 2-(3-Hydroxy-propylamine)-3-(3-methyl-2-butenyl)-[1,4]naphthoquinone using computational prediction models, in addition to evaluating the in vitro antibacterial and modulatory activity of these compounds against…
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Keywords:
antibacterial modulatory;
lapachol;
modulatory activity;
lapachol lapachol ... See more keywords
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Published in 2019 at "Polyhedron"
DOI: 10.1016/j.poly.2019.03.010
Abstract: Abstract Mixed ligand complexes [Cu(phen)(Lap)2] (1) and [Co(dppeO)(Lap)2] (2) were synthesized from the reaction of lapachol (Lap) with [Cu(phen)Cl2] or [Co(dppe)Cl2] in the presence of Et3N. Complexes (1) and (2) were fully characterized by X-ray…
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Keywords:
synthesis characterization;
ligand complexes;
lapachol;
mixed ligand ... See more keywords
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Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra05752e
Abstract: Lapachol is an active compound for the treatment of malignant brain glioma. However, its physicochemical properties limit its clinical application. The purpose of this study is to develop a nano-drug delivery system (LPC-LP) loaded with…
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Keywords:
lpc;
glioma;
lapachol;
brain ... See more keywords