Bioanalytical method development and validation of a liquid chromatography-tandem mass spectrometry method for determination of β-lapachone in human plasma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113466
Abstract: The purpose of this work was to develop and validate a rapid, sensitive and robust liquid chromatography tandem mass spectrometric method for the quantification of β-lapachone in human plasma and to use that method to… read more here.
Keywords: liquid; lapachone; human plasma; method ... See more keywords
β-lapachone and α-nor-lapachone modulate Candida albicans viability and virulence factors.
Sign Up to like & getrecommendations! Published in 2018 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2018.03.004
Abstract: BACKGROUND Candida albicans is the most important fungal pathogen that causes infections in humans, and the search for new therapeutic strategies for its treatment is essential. OBJECTIVE The aim of this study was to evaluate… read more here.
Keywords: virulence; lapachone; treatment; lapachone lapachone ... See more keywords
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101440
Abstract: Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification enzymes, including NQO1. The NQO1 bioactivatable agent β-lapachone can target cells with high NQO1… read more here.
Keywords: sod1; lapachone; inhibition; resistance lapachone ... See more keywords
Photo-Uncaging by C(sp3)-C(sp3) Bond Cleavage Restores β-Lapachone Activity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00398
Abstract: β-Lapachone is an ortho-naphthoquinone natural product with significant antiproliferative activity but suffers from adverse systemic toxicity. The use of photoremovable protecting groups to covalently inactivate a substrate and then enable controllable release with light in… read more here.
Keywords: cleavage; sp3 bond; sp3 sp3; activity ... See more keywords
β-Lapachone Inhibits Lung Metastasis of Colorectal Cancer by Inducing Apoptosis of CT26 Cells
Sign Up to like & getrecommendations! Published in 2017 at "Integrative Cancer Therapies"
DOI: 10.1177/1534735416681638
Abstract: Background: β-Lapachone is a quinone-containing compound found in red lapacho (Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional medicine by several South and Central American indigenous people to treat various types… read more here.
Keywords: ct26 cells; lapachone; metastasis; cancer ... See more keywords
β-lapachone: a promising anticancer agent with a unique NQO1 specific apoptosis in pancreatic cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Current cancer drug targets"
DOI: 10.2174/1568009622666220427121127
Abstract: Cancer, one of the major health problems all over the world, requires more competent drugs for clinical use. One recent possible chemotherapeutic drug under research is β-lapachone. β-lapachone (1,2-naphthoquinone) has promising activity against those tumors… read more here.
Keywords: anticancer agent; pancreatic cancer; lapachone promising; promising anticancer ... See more keywords
Naphthoquinones from Handroanthus impetiginosus promote skin wound healing through Sirt3 regulation
Sign Up to like & getrecommendations! Published in 2020 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2020.43706.10275
Abstract: Objective(s): Lapachone is a natural naphthoquinone-derived compound found in Tabebuia avellanedae. It is well-known for its analgesic, anti-inflammatory, anti-microbial, diuretic, and anti-cancerous effects. However, the wound-healing effects of this compound are not known yet. The… read more here.
Keywords: wound healing; handroanthus impetiginosus; lapachone; skin ... See more keywords
MTHFD2 Blockade Enhances the Efficacy of β-Lapachone Chemotherapy With Ionizing Radiation in Head and Neck Squamous Cell Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.536377
Abstract: Head and Neck Squamous Cell Cancer (HNSCC) presents with multiple treatment challenges limiting overall survival rates and affecting patients' quality of life. Amongst these, resistance to radiation therapy constitutes a major clinical problem in HNSCC… read more here.
Keywords: neck squamous; lapachone; rscc; cell ... See more keywords
β-Lapachone Selectively Kills Hepatocellular Carcinoma Cells by Targeting NQO1 to Induce Extensive DNA Damage and PARP1 Hyperactivation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.747282
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death globally. Currently there is a lack of tumor-selective and efficacious therapies for hepatocellular carcinoma. β-Lapachone (ARQ761 in clinical form) selectively kill NADPH: quinone oxidoreductase… read more here.
Keywords: hepatocellular carcinoma; lapachone; parp1 hyperactivation; hcc ... See more keywords
Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics11060271
Abstract: In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For… read more here.
Keywords: gastroretentive drug; lapachone; mechanically robust; dissolution ... See more keywords