Lapatinib with ECF/X in the first-line treatment of metastatic gastric cancer according to HER2neu and EGFR status: a randomized placebo-controlled phase II study (EORTC 40071)
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-018-3667-8
Abstract: PurposeHER2-targeted therapy with trastuzumab and (CF/X) prolonged overall survival (OS) in metastatic HER2neu+ gastric carcinoma (GC). Lapatinib inhibits both EGFR and HER2neu. We investigated the efficacy and safety of lapatinib with epirubicin (E) + CF/X in GC… read more here.
Keywords: status; her2neu; her2neu egfr; according her2neu ... See more keywords
The GLP-2 analogue elsiglutide reduces diarrhoea caused by the tyrosine kinase inhibitor lapatinib in rats
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DOI: 10.1007/s00280-020-04040-0
Abstract: Purpose Lapatinib is a small molecule tyrosine kinase inhibitor used to treat breast cancer, often in combination with chemotherapy. Diarrhoea commonly occurs in up to 78% of patients undertaking lapatinib treatment. The mechanism of this… read more here.
Keywords: glp analogue; kinase inhibitor; lapatinib; diarrhoea caused ... See more keywords
HER3 PET Imaging Identifies Dynamic Changes in HER3 in Response to HER2 Inhibition with Lapatinib
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DOI: 10.1007/s11307-021-01619-8
Abstract: Standard therapy for HER2+ breast cancers includes HER2 inhibition. While HER2 inhibitors have significantly improved therapeutic outcomes, many patients remain resistant to therapy. An important intrinsic resistance mechanism to HER2 inhibition in some breast cancers… read more here.
Keywords: her2 inhibition; breast; lapatinib; her2 ... See more keywords
Lapatinib-loaded acidity-triggered charge switchable polycarbonate-doxorubicin conjugate micelles for synergistic breast cancer chemotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2020.09.051
Abstract: Stimulus-responsive nanosystem is a powerful method to improve the bioavailability and reduce the side effects of anticancer agents. In the present study, a customized dual pH-responsive micellar nanoplatform (DOX+LAP-M) based on polycarbonate-doxorubicin conjugate micelles was… read more here.
Keywords: charge; lapatinib; dox; doxorubicin ... See more keywords
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter
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DOI: 10.1038/s41598-017-03129-6
Abstract: Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects. Synergistic drug combinations… read more here.
Keywords: neuroblastoma; drug; lapatinib; efflux transporter ... See more keywords
Role of ErbB1 in the Underlying Mechanism of Lapatinib-Induced Diarrhoea: A Review
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DOI: 10.1155/2022/4165808
Abstract: Lapatinib, an orally administered small-molecule tyrosine kinase inhibitor (SM-TKI), is an effective treatment for ErbB2-positive breast cancer. However, its efficacy as one of the targeted cancer therapies has been hampered by several adverse effects, especially… read more here.
Keywords: review; erbb1; lapatinib; induced diarrhoea ... See more keywords
Abstract 4811: Oxygen tension - dependent differences in cancer cell kinome
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4811
Abstract: Current approaches to preclinical cancer research often fail to consider the impact of ambient oxygen (O2; ~21%) on cancer cells. This is also true for hypoxia studies that typically involves cancer cells previously grown in… read more here.
Keywords: tumor cells; lapatinib; cells physioxia; oxygen ... See more keywords
Abstract 3056: Structural optimization of lapatinib analogs for overcoming CNS metastases in breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-3056
Abstract: Due to its role in aggressive disease progression and poor clinical outcomes, HER-2 kinase was considered a vital target in breast cancer (BC). Central nervous system (CNS) metastases represent a significant challenge in HER2+ BC,… read more here.
Keywords: cancer; breast cancer; lapatinib; cns ... See more keywords
Abstract P2-09-28: New quantitative diagnostic method by fluorescence nanoparticle for HER2 positive breast cancer treated with neoadjuvant lapatinib and trastuzumab: The Neo LaTH study (JBCRG-16TR)
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DOI: 10.1158/1538-7445.sabcs17-p2-09-28
Abstract: Background: HER2 (human epidermal growth factor receptor 2) testing performed by IHC (immunohistochemical) methods and FISH (fluorescence in situ hybridization) is semi-quantitative. Exact quantification of HER2 is needed to predict which patients are more or… read more here.
Keywords: fluorescence; trastuzumab; method; lapatinib ... See more keywords
Efficacy and safety of small-molecule TKIs in neoadjuvant treatment of HER2-positive breast cancer: a systematic review and network meta-analysis
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DOI: 10.1186/s12885-025-14404-5
Abstract: This study aimed to evaluate the efficacy and safety of small-molecule TKIs in neoadjuvant treatment of HER2-positive breast cancer using a network meta-analysis approach. A systematic literature search was conducted in the Medline, Embase, and… read more here.
Keywords: cancer; treatment; breast; lapatinib ... See more keywords
Pyrotinib versus lapatinib therapy for HER2 positive metastatic breast cancer patients after first-line treatment failure: A meta-analysis and systematic review
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DOI: 10.1371/journal.pone.0279775
Abstract: Introduction It is critical to select subsequent treatments for patients after the failure of trastuzumab therapy. Following the failure of standard trastuzumab therapy guidelines in the Chinese Society of Clinical Oncology, pyrotinib and capecitabine is… read more here.
Keywords: therapy; lapatinib; breast cancer; metastatic breast ... See more keywords