The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies
Sign Up to like & getrecommendations! Published in 2025 at "mAbs"
DOI: 10.1080/19420862.2025.2543768
Abstract: ABSTRACT Monoclonal antibodies (mAbs) feature a conserved N-linked glycosylation site in the CH2 domain, which exhibits heterogeneities in both occupancy and glycan structures. Previous studies have suggested that the unoccupied (nonglycosylated) variant exhibits decreased thermal… read more here.
Keywords: nonglycosylated variant; forced degradation; large aggregates; mab ... See more keywords