Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202000305
Abstract: Regenerative medicine approaches, specifically stem cell technologies, have demonstrated significant potential to treat a diverse array of pathologies. However, such approaches have resulted in a modest clinical benefit, which may be attributed to poor cell… read more here.
Keywords: reservoir; large animal; delivery; target ... See more keywords
Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202100878
Abstract: Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial design has led to the fabrication of a plethora of promising devices. Pre-clinical testing of any joint repair strategy typically requires the use… read more here.
Keywords: comparison biomaterials; systematic comparison; joint repair; large animal ... See more keywords
Gene therapy with helper-dependent adenoviral vectors: lessons from studies in large animal models
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DOI: 10.1007/s11262-017-1471-x
Abstract: Helper-dependent adenoviral vectors (HDAd) are deleted of all viral genes and they can efficiently transduce a wide variety of dividing and non-dividing cells to mediate high transgene expression levels. Unlike early generation adenoviral vectors, the… read more here.
Keywords: large animal; gene therapy; adenoviral vectors; dependent adenoviral ... See more keywords
Requirements for Proper Immunosuppressive Regimens to Limit Translational Failure of Cardiac Cell Therapy in Preclinical Large Animal Models
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-020-10035-2
Abstract: Various cell-based therapies are currently investigated in an attempt to tackle the high morbidity and mortality associated with heart failure. The need for these therapies to move towards the clinic is pressing. Therefore, preclinical large… read more here.
Keywords: cardiac cell; large animal; preclinical large; immunosuppressive regimens ... See more keywords
Large animal models of thermal injury.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2021.12.015
Abstract: Burn injury results in a triad of inter-related adaptive responses: a systemic inflammatory response, a stress response, and a consequent hypermetabolic state which supports the former two. These pathological responses extend beyond the site of… read more here.
Keywords: thermal injury; burn injury; animal models; models thermal ... See more keywords
Developing a combat-relevant translatable large animal model of heterotopic ossification
Sign Up to like & getrecommendations! Published in 2021 at "Bone Reports"
DOI: 10.1016/j.bonr.2021.101127
Abstract: Heterotopic ossification (HO) refers to ectopic bone formation, typically in residual limbs following trauma and injury. A review of injuries from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) indicated that approximately 70% of… read more here.
Keywords: heterotopic ossification; animal model; large animal; bone ... See more keywords
Design and testing of a controlled electromagnetic spinal cord impactor for use in large animal models of acute traumatic spinal cord injury
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.04.031
Abstract: BACKGROUND Spinal cord injury (SCI) causes debilitating neurological dysfunction and has been observed in warfighters injured in IED blasts. Clinical benefit of SCI treatment remains elusive and better large animal models are needed to assess… read more here.
Keywords: large animal; cord; cord impactor; force ... See more keywords
Genetic engineering a large animal model of human hypophosphatasia in sheep
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DOI: 10.1038/s41598-018-35079-y
Abstract: The availability of tools to accurately replicate the clinical phenotype of rare human diseases is a key step toward improved understanding of disease progression and the development of more effective therapeutics. We successfully generated the… read more here.
Keywords: hypophosphatasia; animal model; large animal; bone ... See more keywords
Gravity-based patterning of osteogenic factors to preserve bone structure after osteochondral injury in a large animal model
Sign Up to like & getrecommendations! Published in 2022 at "Biofabrication"
DOI: 10.1088/1758-5090/ac79cd
Abstract: Chondral and osteochondral repair strategies are limited by adverse bony changes that occur after injury. Bone resorption can cause entire scaffolds, engineered tissues, or even endogenous repair tissues to subside below the cartilage surface. To… read more here.
Keywords: preserve bone; large animal; bone; bone structure ... See more keywords
Large animal models of pressure overload-induced cardiac left ventricular hypertrophy to study remodelling of the human heart with aortic stenosis
Sign Up to like & getrecommendations! Published in 2024 at "Cardiovascular Research"
DOI: 10.1093/cvr/cvae045
Abstract: Abstract Pathologic cardiac hypertrophy is a common consequence of many cardiovascular diseases, including aortic stenosis (AS). AS is known to increase the pressure load of the left ventricle, causing a compensative response of the cardiac… read more here.
Keywords: pressure; hypertrophy; animal models; large animal ... See more keywords
SGLT2 inhibitor empagliflozin prevents anthracycline-induced cardiotoxicity in a large-animal model
Sign Up to like & getrecommendations! Published in 2024 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehae666.3760
Abstract: While the development of cancer therapies has significantly improved the survival of cancer patients, more than 35% of cancer survivors treated with anthracyclines will develop cardiotoxicity. There is currently a lack of preventative therapies against… read more here.
Keywords: sglt2; cardiotoxicity; large animal; empagliflozin ... See more keywords