Modelling gestational diabetes mellitus: large animals hold great promise
Sign Up to like & getrecommendations! Published in 2020 at "Reviews in Endocrine and Metabolic Disorders"
DOI: 10.1007/s11154-020-09617-x
Abstract: Gestational diabetes mellitus (GDM) characterized by hyperglycemia during pregnancy is a risk factor for various maternal and fetal complications. The key pathophysiological mechanisms underlying its development have not been elucidated, largely due to the lack… read more here.
Keywords: large animals; gestational diabetes; human gdm; gdm ... See more keywords
CRISPR in livestock: From editing to printing
Sign Up to like & getrecommendations! Published in 2020 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2020.01.063
Abstract: Abstract Precise genome editing of large animals applied to livestock and biomedicine is nowadays possible since the CRISPR revolution. This review summarizes the latest advances and the main technical issues that determine the success of… read more here.
Keywords: large animals; crispr livestock; crispr; editing printing ... See more keywords
Personalized tissue-engineered veins - long term safety, functionality and cellular transcriptome analysis in large animals.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02011d
Abstract: Tissue engineering is a promising methodology to produce advanced therapy medicinal products (ATMPs). We have developed personalized tissue engineered veins (P-TEV) as an alternative to autologous or synthetic vascular grafts utilized in reconstructive vein surgery.… read more here.
Keywords: personalized tissue; engineered veins; analysis; large animals ... See more keywords
Challenges in the development of chronic pulmonary hypertension models in large animals
Sign Up to like & getrecommendations! Published in 2017 at "Pulmonary Circulation"
DOI: 10.1086/690099
Abstract: Pulmonary hypertension (PH) results in significant morbidity and mortality. Chronic PH animal models may advance the study of PH’s mechanisms, evolution, and therapy. In this report, we describe the challenges and successes in developing three… read more here.
Keywords: large animals; pulmonary hypertension; model; challenges development ... See more keywords
Ultrasonographic diagnosis of femoral fractures in large animals.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Veterinary Medical Association"
DOI: 10.2460/javma.22.02.0081
Abstract: OBJECTIVE Femoral fractures are often catastrophic in large animals. Radiographic diagnosis is limited by patient size and feasibility, especially in ambulatory settings. Ultrasonography is widely available and may provide an alternative to radiography for definitive… read more here.
Keywords: ultrasonography; limb; ultrasonographic diagnosis; diagnosis ... See more keywords
Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2019.00223
Abstract: Rodents are widespread animal models in spinal cord injury (SCI) research. They have contributed to obtaining important information. However, some treatments only tested in rodents did not prove efficient in clinical trials. This is probably… read more here.
Keywords: large animals; cord; reproducible spinal; biomechanically reproducible ... See more keywords
Translational Advances of Hydrofection by Hydrodynamic Injection
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.3390/genes9030136
Abstract: Hydrodynamic gene delivery has proven to be a safe and efficient procedure for gene transfer, able to mediate, in murine model, therapeutic levels of proteins encoded by the transfected gene. In different disease models and… read more here.
Keywords: large animals; procedure; gene delivery; hydrofection ... See more keywords
Mesenchymal Stem Cells in Nerve Tissue Engineering: Bridging Nerve Gap Injuries in Large Animals
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24097800
Abstract: Cell-therapy-based nerve repair strategies hold great promise. In the field, there is an extensive amount of evidence for better regenerative outcomes when using tissue-engineered nerve grafts for bridging severe gap injuries. Although a massive number… read more here.
Keywords: nerve repair; nerve; gap injuries; large animals ... See more keywords
Cardiac Optical Mapping in Situ in Swine Models: A View of the Current Situation
Sign Up to like & getrecommendations! Published in 2020 at "Medicina"
DOI: 10.3390/medicina56110620
Abstract: Optical mapping is recognized as a promising tool for the registration of electrical activity in the heart. Most cardiac optical mapping experiments are performed in ex vivo isolated heart models. However, the electrophysiological properties of… read more here.
Keywords: cardiac optical; large animals; heart; mapping ... See more keywords