Large-conductance Ca2+-activated potassium channels are potently involved in the inverse neurovascular response to spreading depolarization
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.07.026
Abstract: Recurrent spreading depolarizations occur in the cerebral cortex from minutes up to weeks following acute brain injury. Clinical evidence suggests that the immediate reduction of cerebral blood flow in response to spreading depolarization importantly contributes… read more here.
Keywords: spreading depolarization; potassium; large conductance; response spreading ... See more keywords
Large Conductance Variations in a Mechanosensitive Single-Molecule Junction
Sign Up to like & getrecommendations! Published in 2018 at "Nano Letters"
DOI: 10.1021/acs.nanolett.8b02810
Abstract: An appealing feature of molecular electronics is the possibility of inducing changes in the orbital structure through external stimuli. This can provide functionality on the single-molecule level that can be employed for sensing or switching… read more here.
Keywords: molecule; single molecule; quantum interference; large conductance ... See more keywords
Pregnancy Reprograms Large-Conductance Ca2+-Activated K+ Channel in Uterine ArteriesNovelty and Significance
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09059
Abstract: The large-conductance Ca2+-activated K+ (BKCa) channel is of critical importance in pregnancy-mediated increase in uterine artery vasodilation and blood flow. The present study tested the hypothesis that active DNA demethylation plays a key role in… read more here.
Keywords: uterine arteries; pregnancy; large conductance; expression ... See more keywords
Novel description of the large conductance Ca2+‐modulated K+ channel current, BK, during an action potential from suprachiasmatic nucleus neurons
Sign Up to like & getrecommendations! Published in 2017 at "Physiological Reports"
DOI: 10.14814/phy2.13473
Abstract: The contribution of the large conductance, Ca2+‐modulated, voltage‐gated K+ channel current, IBK, to the total current during an action potential (AP) from suprachiasmatic nucleus (SCN) neurons is described using a novel computational approach. An experimental… read more here.
Keywords: channel current; large conductance; conductance ca2; current action ... See more keywords
Small molecule modulation of the large-conductance calcium-activated potassium channel suppresses salicylate-induced tinnitus in mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.763855
Abstract: Tinnitus is the phantom perception of sound that has no external source. A neurological signature of tinnitus, and the frequently associated hyperacusis, is an imbalance between excitatory and inhibitory activity in the central auditory system… read more here.
Keywords: induced tinnitus; activity; conductance calcium; large conductance ... See more keywords
The Large-Conductance, Calcium-Activated Potassium Channel: A Big Key Regulator of Cell Physiology
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.750615
Abstract: Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety of cells and tissues following channel activation. It is now recognized that BK channels undergo a wide range of pre- and post-translational… read more here.
Keywords: large conductance; channel; physiology; physiology large ... See more keywords
Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.750618
Abstract: Diabetes mellitus (DM) is an independent risk of macrovascular and microvascular complications, while cardiovascular diseases remain a leading cause of death in both men and women with diabetes. Large conductance Ca2+-activated K+ (BK) channels are… read more here.
Keywords: conductance ca2; ca2 activated; diabetes mellitus; large conductance ... See more keywords
External Hemin as an Inhibitor of Mitochondrial Large-Conductance Calcium-Activated Potassium Channel Activity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232113391
Abstract: The mitochondrial large-conductance calcium-activated potassium channel (mitoBKCa) is located in the inner mitochondrial membrane and seems to play a crucial role in cytoprotection. The mitoBKCa channel is regulated by many modulators, including activators, such as… read more here.
Keywords: activity; conductance calcium; large conductance; hemin ... See more keywords
Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-α-Induced Inflammation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044087
Abstract: Elevated TNF-α levels in serum and broncho-alveolar lavage fluid of acute lung injury patients correlate with mortality rates. We hypothesized that pharmacological plasma membrane potential (Em) hyperpolarization protects against TNF-α-induced CCL-2 and IL-6 secretion from… read more here.
Keywords: tnf induced; protects tnf; ccl secretion; secretion ... See more keywords
Identification of the Large-Conductance Ca2+-Regulated Potassium Channel in Mitochondria of Human Bronchial Epithelial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26113233
Abstract: Mitochondria play a key role in energy metabolism within the cell. Potassium channels such as ATP-sensitive, voltage-gated or large-conductance Ca2+-regulated channels have been described in the inner mitochondrial membrane. Several hypotheses have been proposed to… read more here.
Keywords: large conductance; channel; bronchial epithelial; conductance ca2 ... See more keywords
Deletion of large-conductance calcium-activated potassium channels promotes vascular remodelling through the CTRP7-mediated PI3K/Akt signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.3724/abbs.2022179
Abstract: The large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling… read more here.
Keywords: pi3k akt; ctrp7; large conductance; calcium activated ... See more keywords