Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3246
Abstract: Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40%… read more here.
Keywords: stat3 mutations; granular lymphocyte; large granular; serum ... See more keywords
Clonal expansion of large granular lymphocytes in patients with spondyloarthritis and psoriatic arthritis treated with TNFα inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04872-w
Abstract: To determine the prevalence of clonal T-large granular lymphocyte (T-LGL) cells in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to define possible risk factors for this condition. We present a cross-sectional analysis with… read more here.
Keywords: psoriatic arthritis; patients spondyloarthritis; lgl; large granular ... See more keywords
Large Granular Lymphocytic Leukemia: Current State of Diagnosis, Pathogenesis and Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Current Oncology Reports"
DOI: 10.1007/s11912-021-01159-y
Abstract: This manuscript aims at updating the knowledge on the clinico-biological characteristics, pathogenesis, and the diagnostic challenges of T-LGLL and CLPD-NK disorders and reviews the advances in the management and treatment of these patients. It has… read more here.
Keywords: granular lymphocytic; large granular; diagnosis; treatment ... See more keywords
Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.09.016
Abstract: Graphical abstract Figure. No caption available. HighlightsNKL cell line used as a model for NK cell large granular lymphocyte leukemia.Exogenous IL‐2 causes tyrosine phosphorylation in STAT1 through 6 in NKL cells.NKL co‐treated with IL‐2 and… read more here.
Keywords: large granular; cytokine; inflammatory cytokine; calcitriol eb1089 ... See more keywords
Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.49
Abstract: Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach read more here.
Keywords: characterization large; genetics; granular lymphocyte; large granular ... See more keywords
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01296-0
Abstract: Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutations. However, the functional effects of STAT3 mutations on primary LGLL cells have not been studied in detail. In this study, we show that… read more here.
Keywords: hypermethylation; granular lymphocyte; large granular; stat3 ... See more keywords
The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.07.004
Abstract: T cell large granular lymphocyte leukemia (T-LGLL) is an interesting case at the intersection of autoimmunity and cancer. In T-LGLL, T cells with somatic pathogenic mutations (mainly in STAT3) are linked to rheumatoid arthritis (RA)… read more here.
Keywords: felty syndrome; somatic mutations; granular lymphocyte; large granular ... See more keywords
Prevalence and significance of large granular lymphocytes in patients with immune thrombocytopenia.
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2144194
Abstract: The association between T-cell large granular lymphocytes (T-LGL) and ITP is uncertain. The aims of this study were to determine the prevalence of T-LGL in patients with ITP and to describe its association with ITP… read more here.
Keywords: patients itp; itp patients; itp; lgl ... See more keywords
Large granular lymphocytic leukemia. Current diagnostic and therapeutic approaches and novel treatment options
Sign Up to like & getrecommendations! Published in 2017 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2017.1284585
Abstract: ABSTRACT Introduction: Large granular lymphocytic leukemia (LGLL) is a low grade lymphoproliferative disorder characterized by the clonal proliferation of large granular lymphocytes (LGL) and recognised by the WHO. The diagnosis and management of these patients… read more here.
Keywords: lymphocytic leukemia; current diagnostic; large granular; leukemia current ... See more keywords
Clinicopathologic and immunophenotypic features in dogs with presumptive large granular lymphocyte leukaemia.
Sign Up to like & getrecommendations! Published in 2022 at "Australian veterinary journal"
DOI: 10.1111/avj.13199
Abstract: Large granular lymphocytic leukaemia (LGLL) has been described in a range of species but has been most commonly reported in humans and dogs. In both species, this neoplasia exhibits diversity in both phenotype and biological… read more here.
Keywords: features dogs; leukaemia; immunophenotypic features; large granular ... See more keywords
CD8‐positive cutaneous lymphoproliferation associated with large granular lymphocyte leukemia in a patient with X‐linked agammaglobulinemia
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.13860
Abstract: Patients with primary immunodeficiency are at increased risk for malignancy, especially hematologic neoplasms. This paper reports a unique case of a 47‐year‐old man with X‐linked agammaglobulinemia who presented with progressive asymptomatic violaceous papules and plaques… read more here.
Keywords: linked agammaglobulinemia; granular lymphocyte; large granular; cd8 positive ... See more keywords