Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3246
Abstract: Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40%… read more here.
Keywords: stat3 mutations; granular lymphocyte; large granular; serum ... See more keywords
Epidemiologic sequential analysis of pure red blood cell aplasia and T-cell large granular lymphocyte leukemia in Korea
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-025-06406-x
Abstract: Pure red cell aplasia (PRCA) is a rare hematologic syndrome characterized by anemia with marked reticulocytopenia and, in Asia, is often accompanied by T-cell large granular lymphocyte leukemia (T-LGL). Minimal research has been done on… read more here.
Keywords: pure red; cell large; cell; cell aplasia ... See more keywords
Biphenotypic NK-Large granular lymphocytic leukemia with aggressive clinical features: a case report and literature review
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DOI: 10.1007/s00277-025-06492-x
Abstract: Natural killer large granular lymphocytic leukemia (NK-LGLL) is a rare and typically indolent lymphoproliferative disorder characterized by clonal expansion of natural killer (NK) cells. We report a case of a 49-year-old man presented with a… read more here.
Keywords: report; leukemia; granular lymphocytic; large granular ... See more keywords
Clonal expansion of large granular lymphocytes in patients with spondyloarthritis and psoriatic arthritis treated with TNFα inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Rheumatology International"
DOI: 10.1007/s00296-021-04872-w
Abstract: To determine the prevalence of clonal T-large granular lymphocyte (T-LGL) cells in patients with spondyloarthritis (SpA) and psoriatic arthritis (PsA) and to define possible risk factors for this condition. We present a cross-sectional analysis with… read more here.
Keywords: psoriatic arthritis; patients spondyloarthritis; lgl; large granular ... See more keywords
Large Granular Lymphocytic Leukemia: Current State of Diagnosis, Pathogenesis and Treatment
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DOI: 10.1007/s11912-021-01159-y
Abstract: This manuscript aims at updating the knowledge on the clinico-biological characteristics, pathogenesis, and the diagnostic challenges of T-LGLL and CLPD-NK disorders and reviews the advances in the management and treatment of these patients. It has… read more here.
Keywords: granular lymphocytic; large granular; diagnosis; treatment ... See more keywords
Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.09.016
Abstract: Graphical abstract Figure. No caption available. HighlightsNKL cell line used as a model for NK cell large granular lymphocyte leukemia.Exogenous IL‐2 causes tyrosine phosphorylation in STAT1 through 6 in NKL cells.NKL co‐treated with IL‐2 and… read more here.
Keywords: large granular; cytokine; inflammatory cytokine; calcitriol eb1089 ... See more keywords
Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach
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DOI: 10.1038/leu.2017.49
Abstract: Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach read more here.
Keywords: characterization large; genetics; granular lymphocyte; large granular ... See more keywords
STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01296-0
Abstract: Large granular lymphocyte leukemia (LGLL) is characterized by somatic gain-of-function STAT3 mutations. However, the functional effects of STAT3 mutations on primary LGLL cells have not been studied in detail. In this study, we show that… read more here.
Keywords: hypermethylation; granular lymphocyte; large granular; stat3 ... See more keywords
Hemolytic versus malproductive anemia in large granular lymphocytic leukemia
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DOI: 10.1038/s41375-024-02323-6
Abstract: a chronic clonal proliferation of either cytotoxic T-(CTLs) or natural killer (NK) cells (T-or NK-LGLL) read more here.
Keywords: hemolytic versus; leukemia hemolytic; versus malproductive; anemia large ... See more keywords
Models for T-large granular lymphocytic leukemia: how to mimic the cellular interplays in malignant autoimmunity
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DOI: 10.1038/s41375-025-02553-2
Abstract: T-large granular lymphocytic leukemia (T-LGLL) is a chronic lymphoproliferative disorder characterized by clonal expansions of cytotoxic T-cells. It presents with cytopenias that are not explained by the typically low leukemic burden. Notably, T-LGLL is frequently… read more here.
Keywords: leukemia mimic; leukemia; granular lymphocytic; large granular ... See more keywords
The spectrum of somatic mutations in large granular lymphocyte leukemia, rheumatoid arthritis, and Felty's syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in hematology"
DOI: 10.1053/j.seminhematol.2022.07.004
Abstract: T cell large granular lymphocyte leukemia (T-LGLL) is an interesting case at the intersection of autoimmunity and cancer. In T-LGLL, T cells with somatic pathogenic mutations (mainly in STAT3) are linked to rheumatoid arthritis (RA)… read more here.
Keywords: felty syndrome; somatic mutations; granular lymphocyte; large granular ... See more keywords