Safety and Feasibility of YC-6 in Patients With Large Hemispheric Infarction: A Randomized Clinical Trial.
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DOI: 10.1161/jaha.124.039157
Abstract: Background Malignant cerebral edema is a critical cause of poor outcomes in large hemispheric infarction and novel neuroprotective agents are urgently needed. We aimed to assess the safety and preliminarily explored the feasibility of YC‐6… read more here.
Keywords: patients large; large hemispheric; hemispheric infarction; trial ... See more keywords
Abstract 6: HRS8179 in Patients with Cerebral Edema after Large Hemispheric Infarction: A Multicenter, Randomized, Double-blinded, Placebo-controlled, Phase 2 Study
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DOI: 10.1161/str.56.suppl_1.6
Abstract: Background: Large hemispheric infarction (LHI) shows a high risk of cerebral edema and neurological deterioration, even leading to death, but it still has limited treatment options. HRS8179 is a selective sulfonylurea receptor 1 inhibitor, which… read more here.
Keywords: large hemispheric; hemispheric infarction; group; cerebral edema ... See more keywords
Single-Center Description of Therapeutic Anticoagulation Practices and Outcomes in Large Hemispheric Infarctions
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DOI: 10.1212/cpj.0000000000200105
Abstract: Background and Objectives Large hemispheric infarctions (LHIs) are associated with significant morbidity and mortality, with limited data on therapeutic anticoagulation (AC) management. We provide a descriptive analysis of the type of therapeutic AC used, the… read more here.
Keywords: hemispheric infarctions; single center; large hemispheric; therapeutic anticoagulation ... See more keywords
Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date
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DOI: 10.2147/dddt.s150043
Abstract: Glyburide (also known as glibenclamide) is a second-generation sulfonylurea drug that inhibits sulfonylurea receptor 1 (Sur1) at nanomolar concentrations. Long used to target KATP (Sur1–Kir6.2) channels for the treatment of diabetes mellitus type 2, glyburide… read more here.
Keywords: trpm4; large hemispheric; glyburide; edema ... See more keywords
Medical management of cerebral edema in large hemispheric infarcts
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DOI: 10.3389/fneur.2022.857640
Abstract: Acute ischemic stroke confers a high burden of morbidity and mortality globally. Occlusion of large vessels of the anterior circulation, namely the intracranial carotid artery and middle cerebral artery, can result in large hemispheric stroke… read more here.
Keywords: medical management; large hemispheric; cerebral edema; management cerebral ... See more keywords
Safety and efficacy of low-dose and long-course tirofiban in large hemispheric infarction
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DOI: 10.3389/fneur.2022.987859
Abstract: Background The clinical efficacy and safety of tirofiban in the treatment of large hemispheric infarction (LHI) remain controversial. Methods This study prospectively enrolled patients with acute LHI who were admitted to Putuo Hospital affiliated with… read more here.
Keywords: hemispheric infarction; tirofiban; large hemispheric; group ... See more keywords