Solvent-assisted synthesis of a shape-persistent chiral polyaza gigantocycle characterized by a very large internal cavity and extraordinarily high amplitude of the ECD exciton couplet.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc10184a
Abstract: A giant, chiral square-shaped octaimine macrocycle has been obtained in a controlled manner from readily available and inexpensive substrates: 9,10-diphenylanthracene-based dialdehyde and trans-1,2-diaminocyclohexane. Reduction of the polyimine led to a chiral octaamine characterized by a… read more here.
Keywords: characterized large; solvent assisted; cavity; assisted synthesis ... See more keywords
Abstract 4995: Premature polyadenylation causes oncogenic truncations of the tumor suppressor genesBRCA1,LATS1andMAGI3in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4995
Abstract: Cleavage and polyadenylation is a fundamental process in the control of gene expression, yet how cancer cells deregulate this process to generate cancer-causing alterations is only beginning to be appreciated. We previously showed that in… read more here.
Keywords: premature polyadenylation; breast cancer; polyadenylation; large internal ... See more keywords