Evaluation of the effect of new formulation, food, or a proton pump inhibitor on the relative bioavailability of the smoothened inhibitor glasdegib (PF-04449913) in healthy volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-017-3472-9
Abstract: PurposeThis phase I open-label study investigated the oral bioavailability of two novel maleate salt-based glasdegib (PF-04449913) tablet formulations (small- and large-particle size) relative to the current clinical formulation (diHCl salt-based). In addition, the effect of… read more here.
Keywords: inhibitor; maleate; formulation; large particle ... See more keywords
A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release
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DOI: 10.1038/s41598-020-57874-2
Abstract: Macrophages are highly specialized in removing large particles including dead cells and cellular debris. When stimulated, delivery of the intracellular lysosomal membranes is required for the formation of plasmalemmal pseudopods and phagosomes. As a key… read more here.
Keywords: particle phagocytosis; particle; trpml1; ca2 ... See more keywords
Old age and underlying interstitial abnormalities are risk factors for development of ARDS after pleurodesis using limited amount of large particle size talc
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DOI: 10.1111/resp.13192
Abstract: Talc pleurodesis is commonly performed to manage refractory pleural effusion or pneumothorax. It is considered as a safe procedure as long as a limited amount of large particle size talc is used. However, acute respiratory… read more here.
Keywords: particle size; pleurodesis; talc; limited amount ... See more keywords
Pullout of geogrids from tire-derived aggregate having large particle size
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DOI: 10.1680/jgein.20.00009
Abstract: Although tire-derived aggregate (TDA) has been used as an alternative backfill in geotechnical engineering applications, the interaction between TDA having large particle sizes (e.g. TDA with a max... read more here.
Keywords: tire derived; geogrids tire; large particle; pullout geogrids ... See more keywords