Molecular characterization of a Trichinella spiralis aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells
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DOI: 10.1371/journal.pntd.0008269
Abstract: Background T. spiralis aspartic protease has been identified in excretion/secretion (ES) proteins, but its roles in larval invasion are unclear. The aim of this study was to characterize T. spiralis aspartic protease-2 (TsASP2) and assess… read more here.
Keywords: larval invasion; protease; spiralis aspartic; aspartic protease ... See more keywords
A novel Trichinella spiralis serine proteinase disrupted gut epithelial barrier and mediated larval invasion through binding to RACK1 and activating MAPK/ERK1/2 pathway
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DOI: 10.1371/journal.pntd.0011872
Abstract: Background Gut epithelium is the first natural barrier against Trichinella spiralis larval invasion, but the mechanism by which larval penetration of gut epithelium is not completely elucidated. Previous studies showed that proteases secreted by T.… read more here.
Keywords: larval invasion; gut; barrier; invasion ... See more keywords
Trichinella spiralis serine protease mediates larval invasion of gut epithelium via binding to CK8 and activating RhoA/ROCK1 pathway
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DOI: 10.1371/journal.pntd.0013725
Abstract: Background Trichinella spiralis adult worms and larvae parasitize respectively in small intestine and skeletal muscles of the same host, and larval invasion of gut mucosa is the pivotal step for T. spiralis infection. A T.… read more here.
Keywords: rock1 pathway; ck8; larval invasion; rhoa rock1 ... See more keywords