Prediction of in vivo genotoxicity of lasiocarpine and riddelliine in rat liver using a combined in vitro-physiologically based kinetic modelling-facilitated reverse dosimetry approach
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DOI: 10.1007/s00204-019-02515-5
Abstract: Pyrrolizidine alkaloids (PAs) are naturally occurring genotoxic compounds, and PA-containing plants can pose a risk to humans through contaminated food sources and herbal products. Upon metabolic activation, PAs can form DNA adducts, DNA and protein… read more here.
Keywords: vivo genotoxicity; genotoxicity; reverse dosimetry; rat ... See more keywords