Assessment of antiviral therapeutics in animal models of Lassa fever.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2019.06.010
Abstract: Lassa virus (LASV) is an emerging zoonotic virus endemic in West Africa that can cause severe haemorrhagic Lassa fever (LF) in humans. LF recently gained international attention as a prominent infectious disease, leading to increasingly… read more here.
Keywords: west africa; therapeutics animal; assessment antiviral; antiviral therapeutics ... See more keywords
A challenging response to a Lassa fever outbreak in a non endemic area of Sierra Leone in 2019 with export of cases to The Netherlands
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2022.02.020
Abstract: Introduction On November 20, 2019, the Sierra Leone International Health Regulations (IHR) National Focal Point was notified of an exported case of Lassa fever in The Netherlands, by a Dutch doctor who previously practiced in… read more here.
Keywords: sierra leone; case; response; lassa fever ... See more keywords
Vaccine platforms for the prevention of Lassa fever
Sign Up to like & getrecommendations! Published in 2019 at "Immunology Letters"
DOI: 10.1016/j.imlet.2019.03.008
Abstract: Abstract Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is endemic throughout much of West Africa. The virus primarily circulates in the Mastomys natalensis reservoir and is transmitted to… read more here.
Keywords: fever vaccine; platforms prevention; fever; vaccine platforms ... See more keywords
Meeting report: WHO consultation on accelerating Lassa fever vaccine development in endemic countries, Dakar, 10-11 September 2019.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.01.017
Abstract: At the time of writing in 2019, there have been 754 confirmed cases of Lassa fever in Nigeria, 21% of whom have died. Lassa is on the priority pathogen list for WHO's R&D Blueprint for… read more here.
Keywords: fever; september 2019; vaccine development; lassa fever ... See more keywords
PREVALENCE AND OUTCOME OF LASSA FEVER AMONG HOSPITALIZED PATIENTS IN EBONYI STATE, NIGERIA, 2018 - 2019.
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DOI: 10.1016/j.virusres.2020.198000
Abstract: Lassa fever (LF) is a viral hemorrhagic illness endemic in West Africa. Annually, about 300,000 - 500,000 people are being infected, with about 5,000 deaths. Symptoms of LF include high grade fever, headache, malaise, abdominal… read more here.
Keywords: outcome; fever; prevalence; ebonyi state ... See more keywords
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24246-w
Abstract: Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a… read more here.
Keywords: field; fever; recombinant antigen; lassa fever ... See more keywords
965. Applying Clinical Prediction Tools to Patients with Lassa Fever
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy209.081
Abstract: Abstract Background Clinical prediction tools such as the Quick Sequential Organ Failure Assessment (qSOFA) and the Modified Early Warning Score (MEWS) have been used to predict mortality from sepsis in high-income countries, but their application… read more here.
Keywords: clinical prediction; prediction tools; patients lassa; lassa fever ... See more keywords
Safety and Pharmacokinetics of LHF-535, a Potential Treatment for Lassa Fever, in Healthy Adults
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DOI: 10.1128/aac.00951-22
Abstract: LHF-535 is a small-molecule antiviral currently under development as a therapeutic option to treat Lassa fever and other viral hemorrhagic fevers of arenavirus origin. The human safety and pharmacokinetics of LHF-535 were evaluated in two… read more here.
Keywords: safety pharmacokinetics; pharmacokinetics lhf; lhf 535; lassa fever ... See more keywords
Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Open"
DOI: 10.1136/bmjopen-2020-036936
Abstract: Introduction Lassa fever (LF) is a severe and often fatal systemic disease in humans and affects a large number of countries in West Africa. Treatment options are limited to supportive care and the broad-spectrum antiviral… read more here.
Keywords: prospective observational; properties irrua; study; irrua ribavirin ... See more keywords
Re-emerging Lassa fever outbreaks in Nigeria: Re-enforcing “One Health” community surveillance and emergency response practice
Sign Up to like & getrecommendations! Published in 2018 at "Infectious Diseases of Poverty"
DOI: 10.1186/s40249-018-0421-8
Abstract: We evaluated the impact of man-made conflict events and climate change impact in guiding evidence-based community “One Health” epidemiology and emergency response practice against re-/emerging epidemics. Increasing evidence of emerging and re-emerging zoonotic diseases including… read more here.
Keywords: response; fever; community; health ... See more keywords
The West Africa Lassa fever Consortium pre-positioned protocol for a Phase II/III adaptive, randomised, controlled, platform trial to evaluate multiple Lassa fever therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.19041.1
Abstract: Background: This is a standardized, pre-positioned protocol for the coordinated evaluation of Lassa fever therapeutics. The protocol is the product of discussions that took place in 2021 and 2022 among international investigators from a wide… read more here.
Keywords: positioned protocol; pre positioned; fever; fever therapeutics ... See more keywords