Modelling the effects of climate and human factor on Lassa fever distribution in Ondo State Nigeria
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DOI: 10.1007/s00484-025-02996-3
Abstract: Lassa fever is an acute viral haemorrhagic disease caused by the Lassa virus. Transmission to humans primarily occurs through direct contact with Mastomys rats or via the ingestion of food or usage of household items… read more here.
Keywords: distribution; ondo state; state nigeria; lassa ... See more keywords
Assessment of antiviral therapeutics in animal models of Lassa fever.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in virology"
DOI: 10.1016/j.coviro.2019.06.010
Abstract: Lassa virus (LASV) is an emerging zoonotic virus endemic in West Africa that can cause severe haemorrhagic Lassa fever (LF) in humans. LF recently gained international attention as a prominent infectious disease, leading to increasingly… read more here.
Keywords: west africa; therapeutics animal; assessment antiviral; antiviral therapeutics ... See more keywords
A challenging response to a Lassa fever outbreak in a non endemic area of Sierra Leone in 2019 with export of cases to The Netherlands
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2022.02.020
Abstract: Introduction On November 20, 2019, the Sierra Leone International Health Regulations (IHR) National Focal Point was notified of an exported case of Lassa fever in The Netherlands, by a Dutch doctor who previously practiced in… read more here.
Keywords: sierra leone; case; response; lassa fever ... See more keywords
Vaccine platforms for the prevention of Lassa fever
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DOI: 10.1016/j.imlet.2019.03.008
Abstract: Abstract Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus (LASV), which is endemic throughout much of West Africa. The virus primarily circulates in the Mastomys natalensis reservoir and is transmitted to… read more here.
Keywords: fever vaccine; platforms prevention; fever; vaccine platforms ... See more keywords
Meeting report: WHO consultation on accelerating Lassa fever vaccine development in endemic countries, Dakar, 10-11 September 2019.
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DOI: 10.1016/j.vaccine.2020.01.017
Abstract: At the time of writing in 2019, there have been 754 confirmed cases of Lassa fever in Nigeria, 21% of whom have died. Lassa is on the priority pathogen list for WHO's R&D Blueprint for… read more here.
Keywords: fever; september 2019; vaccine development; lassa fever ... See more keywords
PREVALENCE AND OUTCOME OF LASSA FEVER AMONG HOSPITALIZED PATIENTS IN EBONYI STATE, NIGERIA, 2018 - 2019.
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DOI: 10.1016/j.virusres.2020.198000
Abstract: Lassa fever (LF) is a viral hemorrhagic illness endemic in West Africa. Annually, about 300,000 - 500,000 people are being infected, with about 5,000 deaths. Symptoms of LF include high grade fever, headache, malaise, abdominal… read more here.
Keywords: outcome; fever; prevalence; ebonyi state ... See more keywords
Identifying risk factors for clinical Lassa fever in Sierra Leone, 2019–2021
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DOI: 10.1017/s095026882400164x
Abstract: Abstract Lassa fever (LF) virus (LASV) is endemic in Sierra Leone (SL) and poses a significant public health threat to the region; however, no risk factors for clinical LF have been reported in SL. The… read more here.
Keywords: risk; lassa fever; factors clinical; risk factors ... See more keywords
Field validation of recombinant antigen immunoassays for diagnosis of Lassa fever
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DOI: 10.1038/s41598-018-24246-w
Abstract: Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a… read more here.
Keywords: field; fever; recombinant antigen; lassa fever ... See more keywords
Virus Load Kinetics in Lassa Fever Patients Treated With Ribavirin: A Retrospective Cohort Study From Southern Nigeria
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DOI: 10.1093/ofid/ofae575
Abstract: Abstract Background The standard of care for Lassa fever is the use of ribavirin with supportive therapy. There is little information on the course of viremia and its relationship with clinical outcomes in patients treated… read more here.
Keywords: load; patients treated; lassa fever; treated ribavirin ... See more keywords
965. Applying Clinical Prediction Tools to Patients with Lassa Fever
Sign Up to like & getrecommendations! Published in 2018 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofy209.081
Abstract: Abstract Background Clinical prediction tools such as the Quick Sequential Organ Failure Assessment (qSOFA) and the Modified Early Warning Score (MEWS) have been used to predict mortality from sepsis in high-income countries, but their application… read more here.
Keywords: clinical prediction; prediction tools; patients lassa; lassa fever ... See more keywords
Safety and Pharmacokinetics of LHF-535, a Potential Treatment for Lassa Fever, in Healthy Adults
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DOI: 10.1128/aac.00951-22
Abstract: LHF-535 is a small-molecule antiviral currently under development as a therapeutic option to treat Lassa fever and other viral hemorrhagic fevers of arenavirus origin. The human safety and pharmacokinetics of LHF-535 were evaluated in two… read more here.
Keywords: safety pharmacokinetics; pharmacokinetics lhf; lhf 535; lassa fever ... See more keywords