Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.07.020
Abstract: Lassa virus (LASV) causes hemorrhagic fever and is endemic in West Africa. Protective antibody responses primarily target the LASV surface glycoprotein (GPC), and GPC-B competition group antibodies often show potent neutralizing activity in humans. However,… read more here.
Keywords: antibody; convergent structures; neutralization; gpc ... See more keywords
Development and Evaluation of a One-Step Quantitative RT-PCR Assay for Detection of Lassa Virus
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virological Methods"
DOI: 10.1016/j.jviromet.2019.113674
Abstract: Abstract Lassa fever is a severe viral hemorrhagic illness caused by Lassa virus. Based on estimates, the number of LASV infections ranges from 300,000 to 500,000 cases in endemic areas with a fatality rate of… read more here.
Keywords: evaluation one; detection; development evaluation; lassa virus ... See more keywords
Alphavirus vector-based replicon particles expressing multivalent cross-protective Lassa virus glycoproteins
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.12.046
Abstract: Lassa virus (LASV) is the most prevalent rodent-borne arenavirus circulated in West Africa. With population at risk from Senegal to Nigeria, LASV causes Lassa fever and is responsible for thousands of deaths annually. High genetic… read more here.
Keywords: replicon particles; cross; alphavirus vector; lassa virus ... See more keywords
Adaptive genetic diversification of Lassa virus associated with the epidemic split of north-central Nigerian and non-Nigerian lineages.
Sign Up to like & getrecommendations! Published in 2020 at "Virology"
DOI: 10.1016/j.virol.2020.03.002
Abstract: Lassa fever (LF) is a viral hemorrhagic fever that causes high morbidity and severe mortality annually. The disease is endemic to two geographically separate areas within tropical West Africa, one in Nigeria and the second… read more here.
Keywords: non nigerian; nigerian non; lassa virus; north central ... See more keywords
Determining Ribavirin’s mechanism of action against Lassa virus infection
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10198-0
Abstract: Ribavirin is a broad spectrum antiviral which inhibits Lassa virus (LASV) replication in vitro but exhibits a minor effect on viremia in vivo. However, ribavirin significantly improves the disease outcome when administered in combination with… read more here.
Keywords: ribavirin; mechanism; infection; lassa virus ... See more keywords
Lassa virus glycoprotein complex review: insights into its unique fusion machinery
Sign Up to like & getrecommendations! Published in 2022 at "Bioscience Reports"
DOI: 10.1042/bsr20211930
Abstract: Abstract Lassa virus (LASV), an arenavirus endemic to West Africa, causes Lassa fever—a lethal hemorrhagic fever. Entry of LASV into the host cell is mediated by the glycoprotein complex (GPC), which is the only protein… read more here.
Keywords: fusion; lassa virus; glycoprotein complex; host cell ... See more keywords
Identifying the genetic basis of viral spillover using Lassa virus as a test case
Sign Up to like & getrecommendations! Published in 2023 at "Royal Society Open Science"
DOI: 10.1098/rsos.221503
Abstract: The rate at which zoonotic viruses spill over into the human population varies significantly over space and time. Remarkably, we do not yet know how much of this variation is attributable to genetic variation within… read more here.
Keywords: lassa virus; identifying genetic; population; virus ... See more keywords
A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains
Sign Up to like & getrecommendations! Published in 2021 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abf6348
Abstract: A single-dose vaccine confers cross-protection and long-term efficacy against Lassa virus in cynomolgus monkeys. One Shot for Lassa Virus Up to 180 million people are at risk for infection with Lassa virus (LASV), and the… read more here.
Keywords: lassa virus; cynomolgus monkeys; heterologous strains; vaccine ... See more keywords
A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus
Sign Up to like & getrecommendations! Published in 2022 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.abq0991
Abstract: Developing potent therapeutics and effective vaccines are the ultimate goals in controlling infectious diseases. Lassa virus (LASV), the causative pathogen of Lassa fever (LF), infects hundreds of thousands annually, but effective antivirals or vaccines against… read more here.
Keywords: glycan shield; lassa virus; protective antibodies; cocktail ... See more keywords
Mutational Analysis of Lassa Virus Glycoprotein Highlights Regions Required for Alpha-Dystroglycan Utilization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00574-17
Abstract: ABSTRACT Lassa virus (LASV) is an enveloped RNA virus endemic to West Africa and responsible for severe cases of hemorrhagic fever. Virus entry is mediated by the glycoprotein complex consisting of a stable-signal peptide, a… read more here.
Keywords: alpha dystroglycan; receptor; lassa virus; cell ... See more keywords
Screening and Identification of Lassa Virus Entry Inhibitors from an FDA-Approved Drug Library
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00954-18
Abstract: Currently, there is no approved therapy to treat Lassa fever; therefore, repurposing of approved drugs will accelerate the development of a therapeutic stratagem. In this study, we screened an FDA-approved library of drugs and identified… read more here.
Keywords: virus entry; drug; entry; lassa virus ... See more keywords