Discovery and Characterization of Rubrinodin Provide Clues into the Evolution of Lasso Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00029
Abstract: Lasso peptides are unique natural products that comprise a class of ribosomally synthesized and post-translationally modified peptides. Their defining three-dimensional structure is a lariat knot, in which the C-terminal tail is threaded through a macrolactam… read more here.
Keywords: lasso peptides; lasso; lasso peptide; rubrinodin ... See more keywords
Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.8b00392
Abstract: Lasso peptides are natural products belonging to the family of ribosomally synthesized and posttranslationally modified peptides (RiPPs) and are defined by their unique topology. Even though lasso peptide biosynthetic gene clusters are found in many… read more here.
Keywords: chaxapeptin; lasso peptides; lasso peptide; production system ... See more keywords
Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01154
Abstract: We report the bioinformatic prediction and structural validation of two lasso peptides, acinetodin and klebsidin, encoded by the genomes of several human-associated strains of Acinetobacter and Klebsiella. Computation of the three-dimensional structures of these peptides… read more here.
Keywords: klebsiella; lasso peptides; klebsidin; rna polymerase ... See more keywords
Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate Tolerance.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c01452
Abstract: Lasso peptides are ribosomally synthesized and post-translationally modified peptide (RiPP) natural products that display a unique lariat-like, threaded conformation. Owing to a locked three-dimensional structure, lasso peptides can be unusually stable toward heat and proteolytic… read more here.
Keywords: lasso peptides; cfb; lasso peptide; cell free ... See more keywords
Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc02695j
Abstract: Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives lasso peptides excellent pharmacokinetic properties,… read more here.
Keywords: lasso peptides; site selective; lasso; generation ... See more keywords
Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817352116
Abstract: Significance Many bacteria produce antimicrobial peptides for survival under stressful conditions. Some of these antimicrobial peptides are lasso peptides, which have a unique lasso-like topology and have generated great interest as a result of their… read more here.
Keywords: lasso peptides; inhibition; peptides microcin; rnap ... See more keywords
Attempting to synthesize lasso peptides using high pressure
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0234901
Abstract: Lasso peptides are unique in that the tail of the lasso peptide threads through its macrolactam ring. The unusual structure and biological activity of lasso peptides have generated increased interest from the scientific community in… read more here.
Keywords: attempting synthesize; lasso peptides; high pressure; synthesize lasso ... See more keywords
Unusual Post-Translational Modifications in the Biosynthesis of Lasso Peptides
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137231
Abstract: Lasso peptides are a subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs) and feature the threaded, lariat knot-like topology. The basic post-translational modifications (PTMs) of lasso peptide contain two steps, including the leader peptide… read more here.
Keywords: lasso peptides; translational modifications; lasso; post translational ... See more keywords