A Mutation‐Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi‐Strains: A Study Using Glycoprotein of LASV
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.70907
Abstract: Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation‐based reverse vaccinology approaches… read more here.
Keywords: wild mutated; lasv; variability; mutation based ... See more keywords
Evaluating the Biological Role of Lassa Viral Z Protein-Mediated RIG-I Inhibition Using a Replication-Competent Trisegmented Pichinde Virus System in an Inducible RIG-IN Expression Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00754-22
Abstract: Lassa virus (LASV) can cause lethal hemorrhagic fever disease in humans but other arenaviruses, such as Pichinde virus (PICV), do not cause obvious disease. We have previously shown that the Z protein of LASV but… read more here.
Keywords: cell; lasv; picv; pichinde virus ... See more keywords
Comparative Evaluation of Standard RT-PCR Assays and Commercial Real-Time RT-PCR Kits for Detection of Lassa Virus
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.05011-22
Abstract: Lassa virus (LASV) is a significant human pathogen causing hemorrhagic fever in West Africa. Increased traveling around the world raises the risk of imported cases to other countries. ABSTRACT Lassa virus (LASV) is a causative… read more here.
Keywords: lasv; lassa virus; detection; real time ... See more keywords
MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0011984
Abstract: West African Mastomys rodents are the primary reservoir of the zoonotic Lassa virus (LASV). The virus causes haemorrhagic Lassa fever and considerable mortality in humans. To date, the role of Mastomys immunogenetics in resistance to,… read more here.
Keywords: lasv; lassa; lassa virus; zoonotic lassa ... See more keywords
Design, Synthesis, and Biological Evaluation of Benzimidazole Derivatives as Potential Lassa Virus Inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041579
Abstract: The Lassa virus (LASV) causes Lassa fever, a highly infectious and lethal agent of acute viral hemorrhagic fever. At present, there are still no effective treatments available, creating an urgent need to develop novel therapeutics.… read more here.
Keywords: design synthesis; synthesis biological; lasv; biological evaluation ... See more keywords
Combating Lassa Fever in West African Sub-Region: Progress, Challenges, and Future Perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Viruses"
DOI: 10.3390/v15010146
Abstract: Lassa fever (LF) is a rodent-borne disease that threatens human health in the sub-region of West Africa where the zoonotic host of Lassa virus (LASV) is predominant. Currently, treatment options for LF are limited and… read more here.
Keywords: lassa; lasv; sub region; lassa fever ... See more keywords