Conditional inactivation of the L‐type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30883
Abstract: Scoliosis, usually diagnosed in childhood and early adolescence, is an abnormal lateral curvature of the spine. L‐type amino acid transporter 1 (LAT1), encoded by solute carrier transporter 7a5 (Slc7a5), plays a crucial role in amino… read more here.
Keywords: scoliosis; transporter; lat1; amino acid ... See more keywords
Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104921
Abstract: l-Type amino acid transporter 1 (LAT1) is an interesting protein due to its peculiar expression profile. It can be utilized not only as a carrier for improved or targeted drug delivery, e.g., into the brain… read more here.
Keywords: amino acid; transporter lat1; type amino; acid transporter ... See more keywords
Structural properties for selective and efficient l‐type amino acid transporter 1 (LAT1) mediated cellular uptake
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.04.025
Abstract: Graphical abstract Figure. No Caption available. Abstract l‐Type amino acid transporter 1 (LAT1) is a sodium‐independent exchanger transporting large neural amino acids and several amino‐acid mimicking drugs across the cell membranes. LAT1 is highly expressed… read more here.
Keywords: amino acid; transporter lat1; type amino; acid transporter ... See more keywords
Advanced Boron Neutron Capture Therapy Targeting Cancer Stem Cells by Selective Induction of LAT1 Overexpression.
Sign Up to like & getrecommendations! Published in 2023 at "Radiation research"
DOI: 10.1667/rade-22-00195.1
Abstract: This study conducted fundamental research to develop a more effective BNCT targeting cancer stem cells. We constructed plasmids that induced the overexpression of L-type amino acid transporter 1 (LAT1) tagged with tdTomato on the cytoplasmic… read more here.
Keywords: cancer stem; lat1; targeting cancer; stem cells ... See more keywords
The Nutraceutical Alliin From Garlic Is a Novel Substrate of the Essential Amino Acid Transporter LAT1 (SLC7A5)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.877576
Abstract: The plasma membrane transporter LAT1 (SLC7A5) is a crucial player for cell homeostasis because it is responsible for providing cells with essential amino acids and hormones. LAT1 forms a functional heterodimer with the cell surface… read more here.
Keywords: lat1 slc7a5; alliin; essential amino; lat1 ... See more keywords
Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2023.1148055
Abstract: Amino acids have diverse and essential roles in many cellular functions such as in protein synthesis, metabolism and as precursors of different hormones. Translocation of amino acids and derivatives thereof across biological membranes is mediated… read more here.
Keywords: transporter; 4f2hc lat1; scintillation proximity; lat1 ... See more keywords
The Anti-Tumor Effect of the Newly Developed LAT1 Inhibitor JPH203 in Colorectal Carcinoma, According to a Comprehensive Analysis
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DOI: 10.3390/cancers15051383
Abstract: Simple Summary The large neutral amino acid transporter family (LAT1-4) plays an important role in the intracellular uptake of essential amino acids. Among them, LAT1 is specifically expressed in cancer cells. A novel LAT1-specific inhibitor,… read more here.
Keywords: anti tumor; jph203; expression; lat1 ... See more keywords
Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20010027
Abstract: The large neutral amino acid transporter 1 (LAT1) is a promising anticancer target that is required for the cellular uptake of essential amino acids that serve as building blocks for cancer growth and proliferation. Here,… read more here.
Keywords: neutral amino; amino; amino acid; lat1 ... See more keywords
The L-Type Amino Acid Transporter LAT1—An Emerging Target in Cancer
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20102428
Abstract: Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are… read more here.
Keywords: amino acid; type amino; acid transporter; lat1 ... See more keywords
Genetic Ablation of LAT1 Inhibits Growth of Liver Cancer Cells and Downregulates mTORC1 Signaling
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119171
Abstract: Through a comprehensive analysis of the gene expression and dependency in HCC patients and cell lines, LAT1 was identified as the top amino acid transporter candidate supporting HCC tumorigenesis. To assess the suitability of LAT1… read more here.
Keywords: cell; liver cancer; mtorc1 signaling; growth ... See more keywords
Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis
Sign Up to like & getrecommendations! Published in 2022 at "World Journal of Gastroenterology"
DOI: 10.3748/wjg.v28.i10.1024
Abstract: BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis (AP) except for LAT1 (slc7a5), the expression of which remains stable. LAT1 supports cell growth by importing leucine and thereby stimulates… read more here.
Keywords: lat1 knockout; recovery; expression; lat1 ... See more keywords