Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2018.11.030
Abstract: Summary Local translation regulates the axonal proteome, playing an important role in neuronal wiring and axon maintenance. How axonal mRNAs are localized to specific subcellular sites for translation, however, is not understood. Here we report… read more here.
Keywords: translation platforms; mrna translation; translation; late endosomes ... See more keywords
Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion
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DOI: 10.1111/acel.13713
Abstract: Autophagy is essential for protein quality control and regulation of the functional proteome. Failure of autophagy pathways with age contributes to loss of proteostasis in aged organisms and accelerates the progression of age‐related diseases. In… read more here.
Keywords: late endosomes; age; secretion; activity ... See more keywords
Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca2+ efflux and disrupted by PSEN1 loss of function
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj5716
Abstract: Dysfunction and mistrafficking of organelles in autophagy- and endosomal-lysosomal pathways are implicated in neurodegenerative diseases. Here, we reveal selective vulnerability of maturing degradative organelles (late endosomes/amphisomes) to disease-relevant local calcium dysregulation. These organelles undergo exclusive… read more here.
Keywords: late endosomes; loss function; endosomes amphisomes; psen1 loss ... See more keywords
The Orthobunyavirus Germiston Enters Host Cells from Late Endosomes
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DOI: 10.1128/jvi.02146-21
Abstract: Orthobunyaviruses (OBVs), which include La Crosse, Oropouche, and Schmallenberg viruses, represent a growing threat to humans and domestic animals worldwide. Ideally, preventing OBV spread requires approaches that target early stages of infection, i.e., virus entry.… read more here.
Keywords: late endosomes; gerv; host cells; penetration ... See more keywords
A Bispecific METxMET Antibody–Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-22-0414
Abstract: Abstract Most antibody–drug conjugates (ADC) approved for the treatment of cancer contain protease-cleavable linkers. ADCs that traffic to lysosomes traverse highly acidic late endosomes, while ADCs that recycle to the plasma membrane traffic through mildly… read more here.
Keywords: metxmet antibody; late endosomes; bispecific metxmet; recycling endosomes ... See more keywords