Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
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DOI: 10.1038/s41467-020-19803-9
Abstract: Hepatic lipogenesis is normally tightly regulated but is aberrantly elevated in obesity. Fibroblast Growth Factor-15/19 (mouse FGF15, human FGF19) are bile acid-induced late fed-state gut hormones that decrease hepatic lipid levels by unclear mechanisms. We… read more here.
Keywords: shp dnmt3a; lipogenesis; fgf15; late fed ... See more keywords