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   Articles with "late ina" as a keyword



Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling

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recommendations! Published in 2019 at "Basic Research in Cardiology"

DOI: 10.1007/s00395-019-0720-7

Abstract: Increased late sodium current (late INa) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca2+ leak. This study investigates the contribution of Ca2+/Calmodulin-dependent kinase… read more here.

Keywords: late sodium; kinase; late ina; ca2 ... See more keywords

Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF

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recommendations! Published in 2024 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvae095

Abstract: Abstract Aims Heart failure with preserved ejection fraction (HFpEF) causes substantial morbidity and mortality. Importantly, atrial remodelling and atrial fibrillation are frequently observed in HFpEF. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have recently been shown to… read more here.

Keywords: atrial cardiomyocytes; increased influx; empagliflozin inhibits; cardiomyocytes patients ... See more keywords

Late sodium current in atrial cardiomyocytes contributes to the induced and spontaneous atrial fibrillation in rabbit hearts.

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recommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"

DOI: 10.1097/fjc.0000000000000883

Abstract: Increased late sodium current (INa) induces long QT syndrome 3 with increased risk of atrial fibrillation (AF). The role of atrial late INa in the induction of AF and in the treatment of AF was… read more here.

Keywords: ina; rabbit hearts; late sodium; atrial fibrillation ... See more keywords

Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation

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recommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"

DOI: 10.1098/rstb.2022.0163

Abstract: Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein… read more here.

Keywords: late sodium; late ina; camkii; atrial fibrillation ... See more keywords

Enhanced Late INa Induces Intracellular Ion Disturbances and Automatic Activity in the Guinea Pig Pulmonary Vein Cardiomyocytes

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recommendations! Published in 2024 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms25168688

Abstract: The effects of enhanced late INa, a persistent component of the Na+ channel current, on the intracellular ion dynamics and the automaticity of the pulmonary vein cardiomyocytes were studied with fluorescent microscopy. Anemonia viridis toxin… read more here.

Keywords: intracellular ion; pulmonary vein; ina; late ina ... See more keywords