Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0720-7
Abstract: Increased late sodium current (late INa) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca2+ leak. This study investigates the contribution of Ca2+/Calmodulin-dependent kinase… read more here.
Keywords: late sodium; kinase; late ina; ca2 ... See more keywords
Late sodium current in atrial cardiomyocytes contributes to the induced and spontaneous atrial fibrillation in rabbit hearts.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000883
Abstract: Increased late sodium current (INa) induces long QT syndrome 3 with increased risk of atrial fibrillation (AF). The role of atrial late INa in the induction of AF and in the treatment of AF was… read more here.
Keywords: ina; rabbit hearts; late sodium; atrial fibrillation ... See more keywords
Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0163
Abstract: Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein… read more here.
Keywords: late sodium; late ina; camkii; atrial fibrillation ... See more keywords