Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling
Sign Up to like & getrecommendations! Published in 2019 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-019-0720-7
Abstract: Increased late sodium current (late INa) is an important arrhythmogenic trigger in cardiac disease. It prolongs cardiac action potential and leads to an increased SR Ca2+ leak. This study investigates the contribution of Ca2+/Calmodulin-dependent kinase… read more here.
Keywords: late sodium; kinase; late ina; ca2 ... See more keywords
Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy
Sign Up to like & getrecommendations! Published in 2017 at "Current Heart Failure Reports"
DOI: 10.1007/s11897-017-0333-0
Abstract: Purpose of reviewOver the last years, evidence is accumulating that enhanced late sodium current (INaL) in cardiac pathologies has fundamental consequences for cellular electrophysiology. This review discusses the underlying mechanisms of INaL-induced arrhythmias and the… read more here.
Keywords: late sodium; sodium current; heart failure; current innovative ... See more keywords
Isoliensinine Eliminates Afterdepolarizations Through Inhibiting Late Sodium Current and L-Type Calcium Current
Sign Up to like & getrecommendations! Published in 2020 at "Cardiovascular Toxicology"
DOI: 10.1007/s12012-020-09597-z
Abstract: Isoliensinine (IL) extracted from lotus seed has a good therapeutic effect on cardiovascular diseases. However, its effect on ion channels of ventricular myocytes is still unclear. We used whole-cell patch-clamp techniques to detect the effects… read more here.
Keywords: late sodium; sodium current; calcium current; type calcium ... See more keywords
Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.01.025
Abstract: SUMMARY Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive,… read more here.
Keywords: cardiac myocytes; late sodium; sumoylation nav1; sodium current ... See more keywords
Increase of late sodium current contributes to enhanced susceptibility to atrial fibrillation in diabetic mice.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172444
Abstract: Studies demonstrated that the incidence of atrial fibrillation is significantly increased in patients with diabetes mellitus. Increase of late sodium current (INaL) has been associated with atrial arrhythmias. However, the role of INaL in the… read more here.
Keywords: atrial fibrillation; late sodium; sodium current; diabetic mice ... See more keywords
Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01056-0
Abstract: Cardiac arrhythmias associated with intracellular calcium inhomeostasis are refractory to antiarrhythmic therapy. We hypothesized that late sodium current (INa) contributed to the calcium-related arrhythmias. Monophasic action potential duration at 90% completion of repolarization (MAPD90) was… read more here.
Keywords: late sodium; sodium current; ventricular arrhythmias; calcium ... See more keywords
Late sodium current and calcium homeostasis in arrhythmogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Channels"
DOI: 10.1080/19336950.2020.1854986
Abstract: ABSTRACT The cardiac late sodium current (INa,late) is the small sustained component of the sodium current active during the plateau phase of the action potential. Several studies demonstrated that augmentation of the current can lead… read more here.
Keywords: ina late; homeostasis; late sodium; sodium current ... See more keywords
Late sodium current in atrial cardiomyocytes contributes to the induced and spontaneous atrial fibrillation in rabbit hearts.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000000883
Abstract: Increased late sodium current (INa) induces long QT syndrome 3 with increased risk of atrial fibrillation (AF). The role of atrial late INa in the induction of AF and in the treatment of AF was… read more here.
Keywords: ina; rabbit hearts; late sodium; atrial fibrillation ... See more keywords
Late sodium current in synergism with Ca2+/calmodulin-dependent protein kinase II contributes to β-adrenergic activation-induced atrial fibrillation
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0163
Abstract: Atrial fibrillation (AF) is frequently associated with β-adrenergic stimulation, especially in patients with structural heart diseases. The objective of this study was to determine the synergism of late sodium current (late INa) and Ca2+/calmodulin-dependent protein… read more here.
Keywords: late sodium; late ina; camkii; atrial fibrillation ... See more keywords
Effects of Allicin on Late Sodium Current Caused by ΔKPQ-SCN5A Mutation in HEK293 Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.636485
Abstract: Aim The aim was to study the effect of Allitridum (Allicin) on the heterologous expression of the late sodium current on the ΔKPQ-SCN5A mutations in HEK293 cells, with a view to screening new drugs for… read more here.
Keywords: inactivation; kpq scn5a; late sodium; sodium current ... See more keywords
Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020231
Abstract: Late sodium current has long been linked to dysrhythmia and contractile malfunction in the heart. Despite the increasing body of accumulating information on the subject, our understanding of its role in normal or pathologic states… read more here.
Keywords: late sodium; heart stand; current heart; sodium current ... See more keywords