Comparison of Early- and Late-Stage Breast and Colorectal Cancer Diagnoses During vs Before the COVID-19 Pandemic
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.48581
Abstract: This quality improvement study compares the incidence of early- and late-stage breast and colorectal cancer diagnoses during vs before the COVID-19 pandemic at a California cancer center. read more here.
Keywords: stage breast; early late; breast colorectal; late stage ... See more keywords
Prevalence of Age-Related Macular Degeneration in the US in 2019.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.4401
Abstract: Importance Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness. AMD prevalence has not been estimated for the US in over a decade and early-stage AMD prevalence estimates are scarce and… read more here.
Keywords: prevalence; stage amd; age; late stage ... See more keywords
Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50837
Abstract: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such… read more here.
Keywords: lewy bodies; dementia lewy; late stage; alzheimer disease ... See more keywords
Recent advances in late‐stage selective deuteration for drug development
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7602
Abstract: Deuteration has emerged as a significant method for investigating kinetic isotope effects in chemical reactions. In recent years, research on deuteration has revealed that this reaction often alters the pharmacokinetic or toxicological properties of drug… read more here.
Keywords: stage selective; selective deuteration; drug; deuteration ... See more keywords
Recent Advances in Late‐Stage Construction of Stapled Peptides via C−H Activation
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DOI: 10.1002/cbic.202100044
Abstract: Stapled peptides have been widely applied in many fields, including pharmaceutical chemistry, diagnostic reagents, and materials science. However, most traditional stapled peptide preparation methods rely on prefunctionalizations, which limit the diversity of stapled peptides. Recently,… read more here.
Keywords: late stage; stage construction; stapled peptides; activation ... See more keywords
Enzymatic Late‐Stage Halogenation of Peptides
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DOI: 10.1002/cbic.202200569
Abstract: The late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide… read more here.
Keywords: stage halogenation; enzymatic late; halogenation; halogenation peptides ... See more keywords
Condensation Domain Editing of the FR900359 Assembly Line Yields a Novel Analog Amenable to Late‐Stage Functionalization
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400491
Abstract: The natural product FR900359 (FR) has generated significant attention lately, due to its characteristics as potent and selective inhibitor of Gq/11 mediated signal transduction of associated G protein‐coupled receptors (GPCRs). This makes FR both a… read more here.
Keywords: stage functionalization; assembly line; novel analog; late stage ... See more keywords
Late‐Stage Functionalization of Glucosides and Aminoglycosides to Combat Resistant Resistance
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DOI: 10.1002/cbic.202500320
Abstract: The rapid emergence of resistant bacteria and the scarcity of the antibiotic pipeline have been a persistent threat to global health. To expand the antibiotic pipeline,the strategy has focused on revitalizing the current antibiotic via… read more here.
Keywords: chemistry; resistance; stage functionalization; functionalization glucosides ... See more keywords
Late‐Stage Diversification of Pyrazoles as Antileishmanial Agents
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DOI: 10.1002/cmdc.202400028
Abstract: N‐Pyrazolylcarboxamides and N‐pyrazolylureas represent promising lead compounds for the development of novel antileishmanial drugs. Herein, we report the late‐stage diversification of 3‐bromopyrazoles 10 A/B and 14 A by Pd‐catalyzed Sonogashira and Suzuki‐Miyaura cross coupling reactions. The electron‐withdrawing… read more here.
Keywords: position; late stage; moiety; stage diversification ... See more keywords
Late-Stage Functionalization and Characterization of Drugs by High-Throughput Desorption Electrospray Ionization Mass Spectrometry.
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DOI: 10.1002/cplu.202100449
Abstract: Late-stage functionalization (LSF) of drug molecules is an approach to generate modified molecules that retain functional groups present in the active drugs. Here, we report a study that seeks to characterize the potential value of… read more here.
Keywords: high throughput; late stage; mass spectrometry;
Late‐Stage Skeletal Muscle Transcriptome in Duchenne Muscular Dystrophy Shows a BMP4‐Induced Molecular Signature
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.70005
Abstract: Duchenne muscular dystrophy (DMD) is a fatal X‐linked recessive disease due to loss‐of‐function variants in the DYSTROPHIN gene. DMD‐related skeletal muscle wasting is typified by an aberrant immune response involving upregulation of the TGFβ family… read more here.
Keywords: skeletal muscle; duchenne muscular; muscle; late stage ... See more keywords