Comparison of Early- and Late-Stage Breast and Colorectal Cancer Diagnoses During vs Before the COVID-19 Pandemic
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.48581
Abstract: This quality improvement study compares the incidence of early- and late-stage breast and colorectal cancer diagnoses during vs before the COVID-19 pandemic at a California cancer center. read more here.
Keywords: stage breast; early late; breast colorectal; late stage ... See more keywords
Prevalence of Age-Related Macular Degeneration in the US in 2019.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA ophthalmology"
DOI: 10.1001/jamaophthalmol.2022.4401
Abstract: Importance Age-related macular degeneration (AMD) is a leading cause of vision loss and blindness. AMD prevalence has not been estimated for the US in over a decade and early-stage AMD prevalence estimates are scarce and… read more here.
Keywords: prevalence; stage amd; age; late stage ... See more keywords
Translocator protein in late stage Alzheimer’s disease and Dementia with Lewy bodies brains
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50837
Abstract: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such… read more here.
Keywords: lewy bodies; dementia lewy; late stage; alzheimer disease ... See more keywords
Recent Advances in Late‐Stage Construction of Stapled Peptides via C−H Activation
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100044
Abstract: Stapled peptides have been widely applied in many fields, including pharmaceutical chemistry, diagnostic reagents, and materials science. However, most traditional stapled peptide preparation methods rely on prefunctionalizations, which limit the diversity of stapled peptides. Recently,… read more here.
Keywords: late stage; stage construction; stapled peptides; activation ... See more keywords
Enzymatic Late‐Stage Halogenation of Peptides
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200569
Abstract: The late‐stage site‐selective derivatisation of peptides has many potential applications in structure‐activity relationship studies and postsynthetic modification or conjugation of bioactive compounds. The development of orthogonal methods for C−H functionalisation is crucial for such peptide… read more here.
Keywords: stage halogenation; enzymatic late; halogenation; halogenation peptides ... See more keywords
Late-Stage Functionalization and Characterization of Drugs by High-Throughput Desorption Electrospray Ionization Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "ChemPlusChem"
DOI: 10.1002/cplu.202100449
Abstract: Late-stage functionalization (LSF) of drug molecules is an approach to generate modified molecules that retain functional groups present in the active drugs. Here, we report a study that seeks to characterize the potential value of… read more here.
Keywords: high throughput; late stage; mass spectrometry;
2,5-Disubstituted Pyrazolo[4,3-c]cinnolin-3-ones
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2744
Abstract: Complementary strategies to 2,5-disubstituted pyrazolo[4,3-c]cinnolin-3-ones are reported herein, providing late stage substituent introduction at either the 2- or the 5-position. Treating a readily prepared 4-thiocinnoline ester with substituted hydrazines afforded late stage access to the… read more here.
Keywords: late stage; disubstituted pyrazolo; cinnolin ones; pyrazolo cinnolin ... See more keywords
Gradual late stage deepening of Gega ice-dammed lake, Tsangpo gorge, southeastern Tibet, indicated by preliminary sedimentary rock magnetic properties
Sign Up to like & getrecommendations! Published in 2018 at "Acta Geophysica"
DOI: 10.1007/s11600-018-0191-5
Abstract: Gega lake, in southeastern Tibet, was formed by the blocking of Yarlung Tsangpo gorge by a glacier and is a well-known example of geomorphological damming. However, the evolution of the damming process at the site… read more here.
Keywords: late stage; southeastern tibet; magnetic properties; dammed lake ... See more keywords
Educational Opportunities for Down-Staging Breast Cancer in Low-Income Countries: an Example from Tanzania
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Education"
DOI: 10.1007/s13187-019-01587-2
Abstract: While more than 90% of breast cancer patients in western countries survive for at least 5 years, the survival rate in Tanzania is less than 45% because of late stage at presentation. The aim of… read more here.
Keywords: late stage; low income; breast cancer; cancer ... See more keywords
Exosomal lipids for classifying early and late stage non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.02.051
Abstract: Lung cancer is the leading cause of cancer deaths in the United States. Patients with early stage lung cancer have the best prognosis with surgical removal of the tumor, but the disease is often asymptomatic… read more here.
Keywords: late stage; lung cancer; non small; cancer ... See more keywords
Transcriptome landscape of the late-stage alcohol-induced osteonecrosis of the human femoral head.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116012
Abstract: Osteonecrosis resulting from heavy ethanol consumption is one of the major causes of nontraumatic osteonecrosis of the femoral head (ONFH). The underlying pathological and molecular mechanisms remain elusive. In this study, we performed deep RNA… read more here.
Keywords: osteonecrosis; late stage; aionfh; femoral head ... See more keywords