Shocking HIV-1 with immunomodulatory latency reversing agents.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunology"
DOI: 10.1016/j.smim.2021.101478
Abstract: The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase)… read more here.
Keywords: latency; hiv immunomodulatory; hiv; shocking hiv ... See more keywords
Discovering the Mechanisms of Wikstroelide E as a Potential HIV-Latency-Reversing Agent by Transcriptome Profiling.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.0c01039
Abstract: The discovery of efficient and specific HIV-latency-reversing agents is critical for HIV therapy. Here, we developed wikstroelide E, a daphnane diterpene from the buds of Wikstroemia chamaedaphne, as a potential HIV-latency-reversing agent that is 2500-fold… read more here.
Keywords: potential hiv; hiv; latency reversing; hiv latency ... See more keywords
Total Synthesis and Biological Evaluation of the Potent HIV Latency-Reversing Agent Ansellone A and its Analogues.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c00151
Abstract: The total synthesis and biological evaluation of the marine sesterterpenoid ansellone A (1), an HIV latency-reversing agent, and its analogues are reported. The key to the success of this synthetic route is a Prins cyclization… read more here.
Keywords: biological evaluation; total synthesis; latency reversing; hiv latency ... See more keywords
Evaluating a New Class of AKT/mTOR Activators for HIV Latency-Reversing Activity Ex Vivo and In Vivo
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.02393-20
Abstract: If combined with immune therapeutics, latency-reversing agents (LRAs) have the potential to reduce the size of the reservoir sufficiently that an engineered immune response can control the virus in the absence of antiretroviral therapy. We… read more here.
Keywords: vivo; new class; latency; latency reversing ... See more keywords
Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
Sign Up to like & getrecommendations! Published in 2020 at "Biology Open"
DOI: 10.1242/bio.052969
Abstract: ABSTRACT Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to pharmacologically reactivate and purge the latent reservoir with latency reactivating agents (LRAs) such as… read more here.
Keywords: latency; harmine; latency reversing; hiv latency ... See more keywords
Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents
Sign Up to like & getrecommendations! Published in 2023 at "Non-Coding RNA"
DOI: 10.3390/ncrna9010005
Abstract: Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency. A negative-sense promoter (NSP) in the 3′ LTR expresses antisense transcripts with coding… read more here.
Keywords: transcription; latency reversing; sense antisense; reversing agents ... See more keywords