Transcriptional Reprogramming during Effector‐to‐Memory Transition Renders CD4+ T Cells Permissive for Latent HIV‐1 Infection
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.09.014
Abstract: &NA; The latent reservoir for HIV‐1 in resting memory CD4+ T cells is the major barrier to curing HIV‐1 infection. Studies of HIV‐1 latency have focused on regulation of viral gene expression in cells in… read more here.
Keywords: hiv infection; cd4 cells; hiv; infection ... See more keywords
Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.
Sign Up to like & getrecommendations! Published in 2018 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00012
Abstract: We have previously reported gnidimacrin (GM), a protein kinase C (PKC) agonist, significantly reduces the frequency of HIV-1 latently infected cells in peripheral blood mononuclear cells (PBMCs) from patients undergoing successful antiretroviral therapy at low… read more here.
Keywords: inhibitor; hiv; hiv latently; latently infected ... See more keywords
Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07157-0
Abstract: Cells harboring latent HIV-1 pose a major obstacle to eradication of the virus. The ‘shock and kill’ strategy has been broadly explored to purge the latent reservoir; however, none of the current latency-reversing agents (LRAs)… read more here.
Keywords: latency; hiv; euphorbia kansui; ingenol derivative ... See more keywords
Bayesian phylogenetic inference of HIV latent lineage ages using serial sequences
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2023.0022
Abstract: HIV evolves rapidly within individuals, allowing phylogenetic studies to infer the history of viral lineages on short time scales. Latent HIV sequences are an exception to this rapid evolution, as their transcriptional inactivity leads to… read more here.
Keywords: latent hiv; hiv; latent reservoir; method ... See more keywords
Ponatinib Represses Latent HIV-1 by Inhibiting AKT-mTOR
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00067-23
Abstract: Although antiretroviral therapy (ART) is effective in suppressing viral replication, it does not cure HIV-1 infection due to the presence of the viral latent reservoir. Rather than reactivating the latent viruses, the “block and lock”… read more here.
Keywords: latent hiv; hiv; reservoir; akt mtor ... See more keywords
Structure-Activity Relationship Analysis of Benzotriazine Analogues as HIV-1 Latency-Reversing Agents
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00888-20
Abstract: “Shock and kill” therapeutic strategies toward HIV eradication are based on the transcriptional activation of latent HIV with a latency-reversing agent (LRA) and the consequent killing of the reactivated cell by either the cytopathic effect… read more here.
Keywords: benzotriazine analogues; hiv; latent hiv; activity ... See more keywords
Thiostrepton Reactivates Latent HIV-1 through the p-TEFb and NF-κB Pathways Mediated by Heat Shock Response
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02328-19
Abstract: Antiretroviral therapy (ART) suppresses HIV-1 replication but fails to cure the infection. The presence of an extremely stable viral latent reservoir, primarily in resting memory CD4+ T cells, remains a major obstacle to viral eradication.… read more here.
Keywords: heat shock; cd4 cells; tsr; latent hiv ... See more keywords
Maraviroc Is Associated with Latent HIV-1 Reactivation through NF-κB Activation in Resting CD4+ T Cells from HIV-Infected Individuals on Suppressive Antiretroviral Therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.01931-17
Abstract: ABSTRACT Maraviroc is a CCR5 antagonist used in the treatment of HIV-1 infection. We and others have suggested that maraviroc could reactivate latent HIV-1. To test the latency-reversing potential of maraviroc and the mechanisms involved,… read more here.
Keywords: antiretroviral therapy; maraviroc; hiv; latent hiv ... See more keywords
Interactions with Commensal and Pathogenic Bacteria Induce HIV-1 Latency in Macrophages through Altered Transcription Factor Recruitment to the Long Terminal Repeat
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.02141-20
Abstract: The major barrier toward the eradication of HIV-1 infection is the presence of a small reservoir of latently infected cells, which include CD4+ T cells and macrophages that escape immune-mediated clearance and the effects of… read more here.
Keywords: hiv infection; hiv; long terminal; latent hiv ... See more keywords
A Two-Color Haploid Genetic Screen Identifies Novel Host Factors Involved in HIV-1 Latency
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DOI: 10.1128/mbio.02980-21
Abstract: A reservoir of latently HIV-1-infected cells persists in the presence of combination antiretroviral therapy (cART), representing a major obstacle for viral eradication. Reactivation of the latent HIV-1 provirus is part of curative strategies which aim… read more here.
Keywords: hiv; latent hiv; hiv latency; host factors ... See more keywords
Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP
Sign Up to like & getrecommendations! Published in 2022 at "Disease Markers"
DOI: 10.1155/2022/6055347
Abstract: The principal barrier for the eradication of HIV/AIDS is the virus latency. One of the effective strategies so called “shock and kill” is to use latency-reversing agents (LRAs) to activate the latent HIV reservoirs and… read more here.
Keywords: reactivate latent; latent hiv; hiv; hiv transcription ... See more keywords